基于静息态fMRI的酒精使用障碍者大尺度脑网络研究  

Large-scale brain network resting-state fMRI study of alcohol use disorder

作　　者：张海波 戴西勇 余金鸣 张建龙 王小广[1,2] 赵虎 ZHANG Hai-bo;DAI Xi-yong;YU Jin-ming;ZHANG Jian-long;WANG Xiao-guang;ZHAO Hu(Faculty of Forensic Medicine,Zhongshan School of Medicine,Sun Yat-sen University,Guangdong 510080,China)

机构地区：[1]中山大学中山医学院法医学系,广东广州510080 [2]广东省法医学转化医学工程技术研究中心,广东广州510080 [3]中山市第三人民医院医学影像科,广东中山528451 [4]中山大学中山医学院 [5]中山市第三人民医院物质依赖科,广东中山528451

出　　处：《影像诊断与介入放射学》2022年第2期89-95,共7页Diagnostic Imaging & Interventional Radiology

基　　金：广东省医学科研基金项目(B2015123);中山市社会公益科技研究项目(2018B1051、2021B1116)。

摘　　要：目的 探讨酒精使用障碍(AUD)患者脑网络内及网络间的静息态功能连接变化。方法 收集38例AUD患者及与之匹配的38例健康志愿者(HC)的静息态BOLD、3D-T1WI图像(Siemens 1.5 T),然后对AUD组进行密西根酒精使用障碍调查量表(MAST),对全部被试进行简易精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)测评,最后分析两组之间脑网络内及网络间的功能连接变化。结果 与HC组比较,AUD组MMSE和MoCA总评分显著偏低(P<0.05),提示AUD患者存在明显的认知功能障碍。功能连接分析发现两组均具有典型的网络内强连接,呈现不同的连接模式。组间差异显示AUD组存在显著的功能连接减低,尤其是在感觉运动网络(SMN)、背侧注意网络(DAN)、突显网络(SN)、默认网络(DMN)(P<0.05,连边FDR校正)。另外,在AUD内DMN与SN之间的功能连接增强。结论 AUD患者脑功能网络连接发生了改变,以DMN为代表的网络功能连接减低与增强,提示脑网络功能的重塑。Objective To investigate the changes in resting-state functional connectivity within and between brain networks in patients with alcohol use disorder(AUD). Methods The blood oxygen level dependence and 3D-T1WI images of 38 patients with AUD and 38 matched healthy volunteers(HC) were acquired on a 1.5 T MRI scanner. The AUD group underwent Michigan Alcohol Screening Test and all subjects were evaluated using the Mini Mental State Examination(MMSE) and Montreal Cognitive Assessment(MoCA). The changes in functional connectivity within and between brain network in both groups were analyzed. Results Compared with HC, the MMSE and MoCA scores in the AUD were significantly lower(P<0.05) suggesting that cognitive deficits existed in the AUD. Both groups had typical hyper-connectivity in the brain network showing different connectivity patterns. The AUD group had significant reduction in functional connectivity(P <0.05, FDR correction), especially in the sensorimotor network(SMN), dorsal attentional network(DAN),salience network(SN), and default mode network(DMN). In addition, functional connection increased between DMN and SN in AUD.Conclusion The decrease and enhancement of connectivity represented by DMN suggest remodeling of the brain network function in AUD.

关 键 词：酒精使用障碍 功能磁共振成像 脑网络 功能连接 模块 

分 类 号：R749.62[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]