多参数磁共振成像评估膀胱癌新辅助化疗及免疫治疗疗效的研究进展  

Recent advances of multiparametric magnetic resonance imaging for evaluating the efficacy of neoadjuvant chemotherapy and immunotherapy of bladder cancer

作　　者：孔令敏 王焕军[1] KONG Ling-min;WANG Huan-jun(Department of Radiology,The First Affiliated Hospital,Sun Yat-sen University,Guangdong 510080,China)

机构地区：[1]中山大学附属第一医院影像科,广东广州510080

出　　处：《影像诊断与介入放射学》2022年第2期132-138,共7页Diagnostic Imaging & Interventional Radiology

基　　金：国家自然科学基金(82071989);广东省自然科学基金面上项目(2021A1515012243);中山大学附属第一医院柯麟新星人才计划(R08028)。

摘　　要：新辅助化疗和/或免疫治疗是肌层浸润性膀胱癌尤其是晚期膀胱癌患者的重要治疗方法。准确预测、评估化疗及免疫治疗疗效是临床面临的巨大挑战。影像学尤其是MRI检查无创无辐射、准确性高且可重复性好,目前已被广泛应用于膀胱癌的术前分期、分级,但对于膀胱癌新辅助化疗及免疫治疗的疗效评估报道较少。本文针对现阶段膀胱癌MRI检查常用序列以及新兴的功能序列应用现状及前景做了系统性总结及展望,以期为膀胱癌新辅助化疗及免疫治疗的MRI评估提供参考。Neoadjuvant chemotherapy and/or immunotherapy are prominent treatment methods for advanced muscle-invasive bladder cancer. Accurately predicting and evaluating the efficacy of neoadjuvant chemotherapy and immunotherapy are major clinical challenges. Medical imaging, especially MRI, has been widely used in preoperative staging and grading of bladder cancer, given its noninvasive, radiation-free, accurate and repeatable advantages. There are few reports evaluating the efficacy of neoadjuvant chemotherapy and immunotherapy for bladder cancer. We summarized the clinical application and recent advances of conventional and new emerging functional MRI sequences as a reference for MRI evaluation and prediction of bladder cancer response to neoadjuvant chemotherapy and immunotherapy.

关 键 词：膀胱癌 新辅助化疗 免疫治疗 磁共振成像 功能成像 

分 类 号：R737.14[医药卫生—肿瘤] R445.2[医药卫生—临床医学]