不同转归细菌性肝脓肿患者的临床特征比较及影响因素分析  

Clinical characteristic and analysis of influencing factors in patients with bacterial liver abscess of different outcomes

作　　者：李春达 潘古杰 茹金城 陈子安 LI Chun-da;PAN Gu-jie;RU Jin-cheng(Department of infectious Diseases,Shaoxing Centerol hospital(Shaoxing Zhejiang,312030)China)

机构地区：[1]绍兴市中心医院感染科,浙江绍兴312030

出　　处：《中西医结合肝病杂志》2022年第4期335-337,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨不同转归细菌性肝脓肿患者的实验室指标水平及影响因素。方法:回顾性分析2017年1月至2019年12月接受诊治的103例细菌性肝脓肿患者的临床资料,按照治疗后患者临床症状是否好转分为好转组(n=53)和恶化组(n=50)。比较两组患者的实验室指标水平,采用Logistic回归分析影响细菌性肝脓肿患者预后的危险因素。结果:恶化组年龄、肝脓肿直径明显高于好转组(P<0.05)。恶化组天门冬氨酸氨基转移酶、碱性磷酸酶、胆固醇、总胆红素水平、凝血酶原时间明显高于好转组,白蛋白、血红蛋白水平明显低于好转组(P<0.05)。多元线性Logistic回归模型分析结果显示,高龄、高碱性磷酸酶水平、凝血酶原时间延长是影响细菌性肝脓肿患者疾病转归的独立危险因素,血红蛋白是促进细菌性肝脓肿患者疾病转归良好的保护因素(P<0.05)。结论:高龄、高碱性磷酸酶水平、凝血酶原时间延长是影响细菌性肝脓肿患者疾病转归的独立危险因素,高血红蛋白水平是影响细菌性肝脓肿患者疾病转归的保护因素。Objective:To investigate the laboratory index levels and influencing factors of patients with bacterial liver abscess with different outcomes.Methods:The clinical data of 103 patients with bacterial liver abscess who were diagnosed and treated in our hospital from January 2017 to December 2019 were retrospectively analyzed. According to whether the clinical symptoms of the patients improved after treatment, they were divided into the improvement group(the clinical symptoms improved after treatment, n=53) and the worsening group(The clinical symptoms worsened or died after treatment, n=50). The levels of laboratory indicators between the two groups were compared, and Logistic regression was used to analyze the risk factors affecting the prognosis of patients with bacterial liver abscess. Results:The age and diameter of liver abscess in the worsening group were significantly higher than those in the improving group(P<0.05). The levels of aspartate aminotransferase, alkaline phosphatase, cholesterol, total bilirubin, and prothrombin time in the deterioration group were significantly higher than those in the improvement group, and the albumin and hemoglobin levels were significantly lower than those in the improvement group(P<0.05). Multivariate linear logistic regression model analysis showed that advanced age, high alkaline phosphatase level, prothrombin time delay are independent risk factors that affect the disease outcome of patients with bacterial liver abscess, and hemoglobin can promote the disease outcome of patients with bacterial liver abscess. Protective factors(P<0.05). Conclusion:Old age, high alkaline phosphatase level, and prolonged prothrombin time are independent risk factors that affect the disease outcome of patients with bacterial liver abscess, and high hemoglobin level is a protective factor that promotes the disease outcome of patients with bacterial liver abscess.

关 键 词：细菌性肝脓肿 实验室指标 预后 危险因素 

分 类 号：R575.4[医药卫生—消化系统]