A nanoconcrete welding strategy for constructing high-performance wound dressing  

作　　者：Yingshuai Wang Yanxia Zhu Penghe Zhao Bin Wei Mingjian Fan Danyang Chen Zhaokui Jin Qianjun He 

机构地区：[1]School of Life Science and Technology,Weifang Medical University,Weifang,Shandong,China [2]Central Laboratory,Longgang District People’s Hospital of Shenzhen&the Third Affiliated Hospital(Provisional)of the Chinese University of Hong Kong,Shenzhen,Guangdong,China [3]School of Biomedical Engineering,Health Science Center,Shenzhen University,No.1066 Xueyuan Road,Shenzhen,518060,Guangdong,China [4]Department of Quantum and Energy Materials,International Iberian Nanotechnology Laboratory(INL),Braga,4715-330,Portugal [5]Center of Hydrogen Science,Shanghai Jiao Tong University,Shanghai,200240,China

出　　处：《Bioactive Materials》2022年第8期31-41,共11页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(51872188);Shenzhen Basic Research Program(SGDX20201103093600004);Special Funds for the Development of Strategic Emerging Industries in Shenzhen(20180309154519685);SZU Top Ranking Project(860-00000210);the PhD Start-up Fund of Natural Science Foundation of Guangdong Province(2018A030310573,2021A1515011155);China Postdoctoral Science Foundation(2018M643171);Center of Hydrogen Science,Shanghai Jiao Tong University,China.

摘　　要：Engineering biomaterials to meet specific biomedical applications raises high requirements of mechanical performances,and simultaneous strengthening and toughening of polymer are frequently necessary but very challenging in many cases.In this work,we propose a new concept of nanoconcrete welding polymer chains,where mesoporous CaCO3(mCaCO_(3))nanoconcretes which are composed of amorphous and nanocrystalline phases are developed to powerfully weld polymer chains through siphoning-induced occlusion,hydration-driven crystallization and dehydration-driven compression of nanoconcretes.The mCaCO_(3) nanoconcrete welding technology is verified to be able to remarkably augment strength,toughness and anti-fatigue performances of a model polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based porous membrane.Mechanistically,we have revealed polymer-occluded nanocrystal structure and welding-derived microstress which is much stronger than interfacial Van der Waals force,thus efficiently preventing the generation of microcracks and repairing initial microcracks by microcracks-induced hydration,crystallization and polymer welding of mCaCO_(3) nanoconcretes.Constructed porous membrane is used as wound dressing,exhibiting a special nanoplates-constructed surface topography as well as a porous structure with plentiful oriented,aligned and opened pore channels,improved hydrophilicity,water vapor permeability,anti-bacterial and cell adherence,in support of wound healing and skin structural/functional repairing.The proposed nanoconcrete-welding-polymer strategy breaks a new pathway for improving the mechanical performances of polymers.

关 键 词：Tissue engineering Mechanical performances Calcium carbonate Mesoporous materials Organic/inorganic nanocomposite Wound dressing 

分 类 号：R78[医药卫生—口腔医学]