A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions  

作　　者：Yanyan Zheng Ang Gao Jiaxiang Bai Qing Liao Yuzheng Wu Wei Zhang Min Guan Liping Tong Dechun Geng Xin Zhao Paul K.Chu Huaiyu Wang 

机构地区：[1]Center for Human Tissues and Organs Degeneration,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China [2]School of Basic Medical Sciences and Forensic Medicine,North Sichuan Medical College,Nanchong,637000,China [3]Department of Orthopaedics,The First Affiliated Hospital of Soochow University,Suzhou,215006,China [4]Department of Physics,Department of Materials Science and Engineering,Department of Biomedical Engineering,City University of Hong Kong,Tat Chee Avenue,Kowloon,Hong Kong,China [5]Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,100190,China [6]Department of Biomedical Engineering,The Hong Kong Polytechnic University,Hong Kong,China

出　　处：《Bioactive Materials》2022年第8期364-376,共13页生物活性材料（英文）

基　　金：financial support from the National Natural Science Foundation of China(Nos.31922040 and 82001965);Shenzhen Science and Technology Research Funding(Nos.SGLH20180625144002074,JCYJ20180507182637685,and JCYJ20190806165616542);Youth Innovation Promotion Association of Chinese Academy of Sciences(Nos.2017416 and 2020353);Guangdong Basic and Applied Basic Research Foundation(No.2020B1515120078);China Postdoctoral Science Foundation(2019M663190);SIAT Innovation Program for Excellent Young Researchers(E1G034);Nanchong Science and Technology Project(No.20SXQT0302);City University of Hong Kong Strategic Research Grant(SRG)(No.7005505).

摘　　要：Polyetheretherketone(PEEK)is a desirable alternative to conventional biomedical metals for orthopedic implants due to the excellent mechanical properties.However,the inherent bioinertness of PEEK contributes to inferior osseointegration of PEEK implants,especially under pathological conditions of osteoporosis.Herein,a programmed surface is designed and fabricated on PEEK to dictate osteoimmunomodulation and bone regeneration sequentially.A degradable hybrid coating consisting of poly(lactide-co-glycolide)and alendronate(ALN)loaded nano-hydroxyapatite is deposited on PEEK and then interleukin-4(IL-4)is grafted onto the outer surface of the hybrid coating with the aid of N_(2) plasma immersion ion implantation and subsequent immersion in IL-4 solution.Dominant release of IL-4 together with ALN and Ca^(2+) during the first few days synergistically mitigates the early acute inflammatory reactions and creates an osteoimmunomodulatory microenvironment that facilitates bone regeneration.Afterwards,slow and sustained delivery of ALN and Ca^(2+) in the following weeks boosts osteogenesis and suppresses osteoclastogenesis simultaneously,consequently ameliorating bone-implant osseointegration even under osteoporotic conditions.By taking into account the different phases in bone repair,this strategy of constructing advanced bone implants with sequential functions provides customizable and clinically viable therapy to osteoporotic patients.

关 键 词：POLYETHERETHERKETONE Surface modification Osteoimmunomodulation Sequential release OSTEOPOROSIS OSSEOINTEGRATION 

分 类 号：R318[医药卫生—生物医学工程] TB3[医药卫生—基础医学]