A hydrogel spinal dural patch with potential anti-inflammatory,pain relieving and antibacterial effects  

作　　者：Jiahao Li Jingjing Tian Chunxu Li Longyun Chen Yu Zhao 

机构地区：[1]Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [2]Medical Science Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [3]Department of Pathology,State Key Laboratory of Complex Severe and Rare Disease,Molecular Pathology Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China

出　　处：《Bioactive Materials》2022年第8期389-401,共13页生物活性材料（英文）

基　　金：supported by Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program(20191080871);the National Natural Science Foundation of China(82002314).

摘　　要：CSFL caused by spinal dural defect is a common complication of spinal surgery,which need repair such as suture or sealants.However,low intracranial pressure symptoms,wound infection and prolonged hospital associated with pin-hole leakage or loose seal effect were often occurred after surgical suture or sealants repair.Stable,pressure resistance and high viscosity spinal dural repair patch in wet environment without suture or sealants was highly needed.Herein,a bioactive patch composed of alginate and polyacrylamide hydrogel matrix cross-linked by calcium ions,and chitosan adhesive was proposed.This fabricated patch exhibits the capabilities of promoting defect closure and good tight seal ability with the bursting pressure is more than 790 mm H2O in wet environment.In addition,the chitosan adhesive layer of the patch could inhibit the growth of bacterial in vitro,which is meaningful for the postoperative infection.Furthermore,the patch also significantly reduced the expression of GFAP,IBA-1,MBP,TNF-α,and COX-2 in early postoperative period in vivo study,exerting the effects of anti-inflammatory,analgesic and adhesion prevention.Thus,the bioactive patch expected to be applied in spinal dural repair with the good properties of withstanding high pressure,promoting defect closure and inhibiting postoperative infection.

关 键 词：Alginate hydrogel Chitosan adhesive Dural defect repair ANTI-INFLAMMATORY BACTERIOSTASIS 

分 类 号：R73[医药卫生—肿瘤]