慢性阻塞性肺疾病合并肺癌的免疫和遗传研究进展  

Progress in immunologic and genetic research of chronic obstructive pulmonary disease with lung cancer

作　　者：刘云欢 葛海燕[1] 朱惠莉[1] Liu Yunhuan;Ge Haiyan;Zhu Huili(Department of Respiratory and Critical Care Medicine,Huadong Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华东医院呼吸与危重症医学科,上海200040

出　　处：《中华结核和呼吸杂志》2022年第4期409-414,共6页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金(81871100);国家重点研发计划(2020YFC2009001);上海市临床重点专科建设项目(shslczdzk02801);上海市科学技术委员会科研项目(21140902500);上海市卫生健康委员会科研项目(202140036)。

摘　　要：慢性阻塞性肺疾病(简称慢阻肺)和肺癌是当今病死率最高的两大呼吸系统疾病,给人类健康造成严重威胁,给社会和家庭带来巨大负担。慢阻肺合并肺癌的机制非常复杂,为更好理清两者关系,本文从免疫角度和基因角度对现有研究进行逐一梳理。其中,免疫聚焦中性粒细胞及巨噬细胞的固有免疫和B细胞及T细胞的获得性免疫及氧化应激角度,基因聚焦遗传易感基因和调控microRNA角度。本文全面阐释慢阻肺合并肺癌的机制,以期对未来机制的研究、诊断和靶向治疗等临床方面的探索提供有益方向。Chronic obstructive pulmonary disease(COPD)and lung cancer are two of the respiratory diseases with the highest mortality,which have posed huge threat to human health and brought great burden to society and family.The mechanism of COPD with lung cancer is very complicated.In order to clarify the linkage between these two diseases,this review summarized the present researches of COPD and lung cancer from the aspects of immunology and genetics.The immunologic aspect focused on innate immune of neutrophil and macrophage,adaptive immune of B cell,T cell and oxidative stress.The genetic aspect focused on susceptibility gene and microRNA.Through the thorough elaboration of these researches,we hope to provide useful insights into the further research of mechanism,diagnosis and targeted therapy of COPD with lung cancer.

关 键 词：慢性阻塞性肺疾病 呼吸系统疾病 固有免疫 遗传易感基因 靶向治疗 中性粒细胞 巨噬细胞 氧化应激 

分 类 号：R563.9[医药卫生—呼吸系统] R734.2[医药卫生—内科学]