Biomaterial scaffolds for clinical procedures in endodontic regeneration  

作　　者：He Liu Jing Lu Qianzhou Jiang Markus Haapasalo Junrong Qian Franklin R.Tay Ya Shen 

机构地区：[1]Department of Stomatology,Affiliated Hospital of Jining Medical University,China [2]Division of Endodontics,Department of Oral Biological and Medical Sciences,Faculty of Dentistry,University of British Columbia,Canada [3]Key Laboratory of Oral Disease,School and Hospital of Stomatology,Fujian Medical University,Fuzhou,China [4]Department of Endodontics,Stomatology Hospital of Guangzhou Medical University,Guangzhou,China [5]Department of Endodontics,The Dental College of Georgia,Augusta University,Augusta,GA,USA

出　　处：《Bioactive Materials》2022年第6期257-277,共21页生物活性材料（英文）

摘　　要：Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics.These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed to have poor prognosis.As a component biological triad of tissue engineering(i.e.,stem cells,growth factors and scaffolds),biomaterial scaffolds have demonstrated clinical potential as an armamentarium in regenerative endodontic procedures and achieved remarkable advancements.The aim of the present review is to provide a broad overview of biomaterials employed for scaffolding in regenerative endodontics.The favorable properties and limitations of biomaterials organized in naturally derived,host-derived and synthetic material categories were discussed.Preclinical and clinical studies published over the past five years on the performance of biomaterial scaffolds,as well as current challenges and future perspectives for the application of biomaterials for scaffolding and clinical evaluation of biomaterial scaffolds in regenerative endodontic procedures were addressed in depth.

关 键 词：BIOMATERIALS Clinical approach Regenerative endodontics Scaffolds 

分 类 号：R318[医药卫生—生物医学工程] R78[医药卫生—基础医学]