The use of polyisobutylene-based polymers in ophthalmology  

作　　者：Leonard Pinchuk 

机构地区：[1]Distinguished Research Professor of Biomedical Engineering,University of Miami,Biomedical Engineering Dept.,13704 SW 92nd Court,Miami,33176,FL,United States [2]Founder and Senior Vice President,InnFocus,Inc.,a Santen company,Miami,FL,United States

出　　处：《Bioactive Materials》2022年第4期185-194,共10页生物活性材料（英文）

摘　　要：A novel polyolefin called poly(styrene-block-isobutylene-block-styrene)(“SIBS”)originated from Joseph P.Kennedy’s laboratory at the University of Akron(Akron,Ohio,United States)and was developed as a biomaterial for long-term implant applications by the author.SIBS has no cleavable groups on its backbone or sidechains,is comprised predominantly of alternating secondary and quaternary carbons on its backbone,which prevents embrittlement and cracking under flexion,and undergoes multiple purification steps which renders it extremely biocompatible and well-suited for long-term applications in the eye.This article explores two ophthalmic devices;1)the PRESERFLO®MicroShunt(Santen Pharmaceutical Co.Ltd.,Osaka,Japan)made from SIBS that lowers intraocular pressure to thwart progression of vision loss from glaucoma,and 2)a novel intraocular lens(IOL)made from crosslinked polyisobutylene,which is under-development by Xi’an Eyedeal Medical Technology Co.,Ltd.(Xi’an,China)that does not glisten nor cloud over time,as do most conventional IOLs.

关 键 词：Poly(styrene-block-isobutylene-block-styrene) SIBS Glaucoma MicroShunt Intraocular Lens IOL POLYISOBUTYLENE Cataract 

分 类 号：TB33[一般工业技术—材料科学与工程] R77[医药卫生—眼科]