Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine:A review  

作　　者：Nur Ellene Mat Luwi Suhana Ahmad Ahmad Suhaimi Nurfatihah Azlyna Asyikin Nordin Maria Elena Sarmiento Armando Acosta Mohd Nor Norazmi Vuk Uskoković Rohimah Mohamud Ramlah Kadir 

机构地区：[1]Department of Immunology,School of Medical Sciences,Universiti Sains Malaysia,16150 Kubang Kerian,Kelantan,Malaysia [2]School of Health Sciences,Universiti Sains Malaysia,16150 Kubang Kerian,Kelantan,Malaysia [3]Department of Mechanical Engineering,San Diego State University,Campanile Dr.5500,San Diego 921982,CA,USA [4]TardigradeNano LLC,Irvine,CA 92604,USA

出　　处：《Asian Pacific Journal of Tropical Medicine》2022年第1期7-16,共10页亚太热带医药杂志（英文版）

基　　金：supported by Fundamental Research Grant Scheme (FRGS/1/2018/SKK08/USM/03/1),Ministry of Higher Education (Malaysia);Long-term Research Grant Scheme (LRGS/1/2015/USM/01/1/1),Ministry of Higher Education (Malaysia)

摘　　要：Liposomes are phospholipid bilayer vesicles,which are biocompatible,biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery applications.In this review,we discuss the prospect of using liposome technology in the development of a vaccine for tuberculosis.Tuberculosis remains an important health problem that requires the development of an effective vaccine,especially since the only approved vaccine for it continues to be the Bacille Calmette-Geurin(BCG)one developed 100 years ago.This review focuses on the different applications of liposomes toward achieving this goal.Numerous liposomal formulations showing prospect in the research stage and in clinical trials are discussed.

关 键 词：Liposomes Tuberculosis vaccine ADJUVANT Delivery system TUBERCULOSIS 

分 类 号：R392[医药卫生—免疫学]