解读癌症研究的里程碑:Hallmarks of Cancer  

Milestone of cancer research:Hallmarks of Cancer

作　　者：陶青 石毓君[1] TAO Qing;SHI Yujun(Institute of Clinical Pathology,Key Laboratory of Transplant Engineering and Immunology,NHC,West China Hospital,Sichuan University,Chengdu 610041,P.R.China)

机构地区：[1]四川大学华西医院临床病理研究所卫健委移植工程与移植免疫重点实验室,成都610041

出　　处：《中国普外基础与临床杂志》2022年第4期431-433,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：征服癌症是人类永恒的话题。20世纪后半叶,肿瘤研究开始进入分子时代,癌症复杂多样的表型、机制及治疗反应逐渐被认识。2000年,一篇开创性综述“Hallmarks of Cancer”问世,更新至今,已总结出了癌症的14个特征,将肿瘤研究中日益繁杂的概念提炼成一门逻辑科学,有助于更全面地理解癌症发生、发展机制并将这些知识应用于肿瘤的诊断和治疗中,掌握、应用以及继续探索癌症的特征必将有助于在未来更加自信地面对肿瘤疾病带来的挑战。Cancer remains a great challenge for mankind.The complex and diverse phenotypes,mechanisms,as well as therapeutic responsiveness of cancer have gradually been understood since the second half of the 20 th century,which was a representative of entering the molecular era of oncology research.In 2000,the groundbreaking review“Hallmarks of Cancer”came out and it had been updated to the third version with 14 characteristics of cancer in 2022.These series of reviews helped to distil the increasingly complicated concepts of oncology into a logical science,which contributed to a more comprehensive understanding of the mechanisms for cancer genesis and development and applying the knowledges to the diagnosis and treatment of tumors.Mastering,applying,and exploring the hallmarks of cancer will help us face the challenges of cancer more confidently in the future.

关 键 词：癌症特征 肿瘤学 抗癌药物 

分 类 号：R73[医药卫生—肿瘤]