磷酸化的MAPK作用激酶1表达与鼻咽癌发生发展及预后的关系  

Relationship between the expression of phosphorylated MAP kinase integrating kinase 1 and the occurrence,development and prognosis of nasopharyngeal carcinoma

作　　者：张贵[1] 尚蕾 李晓玲 代文意 李颖[2] ZHANG Gui;SHANG Lei;LI Xiaoling;DAI Wenyi;LI Ying(Department of Otorhinolaryngology,Nanyang Central Hospital,Nanyang,Henan 473000,China;Department of Otorhinolaryngology,Children's Hospital Affiliated to Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,Henan 450007,China)

机构地区：[1]南阳市中心医院耳鼻咽喉科,河南南阳473000 [2]郑州大学附属儿童医院、河南省儿童医院、郑州儿童医院耳鼻咽喉科,河南郑州450007

出　　处：《安徽医药》2022年第5期1031-1034,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨磷酸化的MAPK作用激酶1(pMnK1)表达与鼻咽癌病人发生发展及预后的关系。方法选取2015年1月至2017年7月南阳市中心医院收集的90例鼻咽癌病理学标本、90例经病理学检查证实鼻部慢性炎症的鼻黏膜组织(对照组),应用免疫组化染色分析检测pMnk1蛋白表达,并按照年龄、性别、组织学类型、临床分期、淋巴结转移情况进行分组分析,分析pMnk1蛋白阳性与阴性表达的鼻咽癌病人2年生存率及预后。结果鼻咽癌组的pMnK1蛋白阳性率74.44%高于对照组的26.67%,差异有统计学意义(P<0.05);不同TNM分期、淋巴结转移的鼻咽癌组的pMnK1蛋白阳性率比较,差异有统计学意义(P<0.05);经2年随访,pMnK1蛋白阳性的鼻咽癌病人失访4例、阴性病人失访1例,pMnK1蛋白阳性的鼻咽癌病人2年生存率61.90%与阴性病人的77.27%,差异无统计学意义(P>0.05);pMnK1蛋白阳性的鼻咽癌病人的生存时间20.0个月短于阴性组23.0个月,差异有统计学意义[Log-rank(Mantel-Cox)=3.285,P<0.05]。结论鼻咽癌组织中pMnK1蛋白呈高表达,并且与肿瘤的发生发展及不良预后关系密切。Objective To investigate the relationship between the expression of phosphorylated MAP kinase integrating kinase 1(p-MnK1)and the occurrence,development and prognosis of nasopharyngeal carcinoma(NPC)patients.Methods A total of 90 pathological specimens of nasopharyngeal carcinoma and 90 nasal mucosa tissues(control group)with chronic inflammation confirmed by pathological examination were selected from Nanyang Central Hospital from January 2015 to July 2017.The expression of p-Mnk1 protein was detected by immunohistochemical staining,and grouped according to age,sex,histological type,clinical stage,and lymph node metastasis.The 2-year survival rate and prognosis of NPC patients with positive and negative expression of p-Mnk1 protein were analyzed.Results The positive rate of p-MnK1 protein in the NPC group was 74.44%,which was significantly higher than that in the control group(26.67%,P<0.05).The positive rate of p-MnK1 protein in the NPC group with different TNM stages and lymph node metastasis was compared,and the difference was statistically significant(P<0.05).After 2-years of follow-up,4 patients with p-MnK1 protein-positive NPC were lost to follow-up,1 patient with negative p-MnK1 protein was lost to follow-up,and 1 patient with p-MnK1 protein-posi⁃tive NPC was lost to follow-up.The 2-year survival rate of p-MnK1 protein-positive NPC patients was 61.90%and 77.27%of negative patients,and the difference was not statistically significant(P>0.05).The survival time of p-MnK1 protein-positive NPC patients was 20.0 months shorter than that of the negative group(23.0 months),and the difference was statistically significant[log-rank(Mantel-Cox)=3.285,P<0.05].Conclusion The high expression of p-MnK1 protein in NPC tissue is closely related to the occurrence and development of tumors and poor prognosis.

关 键 词：鼻咽肿瘤 磷酸化的MAPK作用激酶1 预后 

分 类 号：R739.63[医药卫生—肿瘤]