河南省某综合医院就诊的自然不孕适龄人群中TORCH感染状况分析  

The analysis of TORCH infection among natural infertility population of childbearing age in a general hospital of Henan Province

作　　者：王万海[1,2] 田向向 张一凡 常谦 孟宪春[1] 王庆芳[1] 李阳[1] 明亮[1] WANG Wan-hai;TIAN Xiang-xiang;ZHANG Yi-fan;CHANG Qian;MENG Xian-chun;WANG Qing-fang;LI Yang;MING Liang(Department of Clinical Laboratory,the First Affiliated Hospital of Zheng Zhou University;Henan Key Laboratory of laboratory medicine,Henan Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院检验科河南省检验医学重点实验室,河南郑州450052 [2]郑州大学医学检验系

出　　处：《江苏预防医学》2022年第2期163-165,共3页Jiangsu Journal of Preventive Medicine

基　　金：河南省医学科技攻关计划项目(201702038);河南省自然科学基金(162300410288)。

摘　　要：目的了解医院就诊的自然不孕人群中弓形虫(Tox)、风疹病毒(RV)、巨细胞病毒(CMV)、单纯疱疹病毒Ⅰ型(HSVI)和单纯疱疹病毒Ⅱ型(HSVII)(合称TORCH)感染情况,为优生优育工作提供临床指导。方法采用酶联免疫吸附试验(ELISA),对2019年某综合医院因自然不孕就诊的适龄男女20585人,进行TORCH特异性IgM和IgG抗体检测。结果20585人中TORCH IgM抗体总阳性率为2.61%,其中RV IgM、Tox IgM抗体阳性率较高(0.98%、0.94%)。CMV IgG抗体阳性率最高(95.27%),其次是HSV I IgG(91.90%)和RV IgG(91.80%);>35岁组RV IgG抗体阳性率(90.02%)低于20~35岁组(92.34%),HSVⅠIgG(93.94%)、HSVⅡIgG(15.33%)均高于20~35岁组(91.28%、10.02%),差异均有统计学意义(P值均<0.05);其他病原体IgG抗体和IgM抗体阳性率不同年龄组间差异均无统计学意义(P值均>0.05)。女性RV IgM抗体阳性率(0.67%)低于男性(1.38%),差异有统计学意义(P<0.05),其他病原体IgM抗体阳性率性别间差异均无统计学意义(P值均>0.05)。女性CMV、HSVⅠ、HSVⅡ的IgG抗体阳性率(96.20%、93.39%、14.26%)均高于男性(94.08%、89.98%、7.39%),Tox、RV的IgG抗体阳性率(4.44%、90.87%)均低于男性(5.34%、93.00%),差异均有统计学意义(P值均<0.05)。除RV IgM抗体阳性率不同月份间差异无统计学意义(P>0.05),其他指标IgM抗体阳性率不同月份间差异均有统计学意义(P值均<0.05)。结论河南省自然不孕接受医学干预人群TORCH病原体近期感染率较低,TORCH感染与年龄、性别、月份有关。Objective To study the infection rate of Toxoplasma gondii(Tox),rubella virus(RV),cytomegalovirus(CMV),herpes simplex virusⅠ(HSVI),herpes simplex virusⅡ(HSVⅡ)(known as TORCH)among natural infertility population of childbearing age in a hospital;to provide clinical guidance for eugenics.Methods Enzyme-linked immunosorbent assay(ELISA)was applied to detect plasma TORCH-IgM and-IgG among 20585 patients of childbearing age for infertility in a hospital in 2019.Results For the 20585 patients,the total positive rate of anti-TORCH-IgM was 2.61%.The positive rates of anti-RV-IgM(0.98%)and anti-Tox-IgM(0.94%)were relatively high;while positive rate of anti-CMV-IgG was the highest(95.27%),followed by anti-HSVⅠ-IgG(91.90%)and anti-RV-IgG(91.80%).The positive rate of anti-RV-IgG antibody in the group aged over 35 years old(90.02%)was lower than that in the group aged 20-35 years(92.34%),while the positive rates of anti-HSVⅠ-IgG(93.94%)and anti-HSVⅡ-IgG(15.33%)were higher than those in the group aged 20-35 years(91.28%and 10.02%,respectively),all differences were statistically significant(all P<0.05).No significant difference were found among the positive rates of IgG and IgM antibodies of other pathogens among different age groups(all P>0.05).The positive rate of anti-RV-IgM in female(0.67%)was lower than that in male(1.38%),the difference was statistically significant(P<0.05),and there was no significant difference between the positive rates of IgM antibodies for other pathogens(all P>0.05).The positive rates of CMV,HSVⅠand HSVⅡIgG antibodies in female(96.20%,93.39%and 14.26%,respectively)were higher than those in male(94.08%,89.98%and 7.39%,respectively),while the positive rates of TOX and RV IgG antibodies(4.44%and 90.87%,respectively)were lower than those in male(5.34%and 93.00%,respectively),all differences were statistically significant(all P<0.05).Except for the positive rate of anti-RV-IgM in different months(P>0.05),there were significant differences among the positive rates of IgM antibodies in othe

关 键 词：巨细胞病毒 单纯疱疹病毒Ⅰ/Ⅱ型 风疹病毒 弓形虫 自然不孕适龄人群 

分 类 号：R[医药卫生]