Helical Nonfouling Polypeptides for Biomedical Applications  

作　　者：Chong Zhang Hua Lu 

机构地区：[1]Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen 518055,China [2]Beijing National Laboratory for Molecular Sciences,Center for Soft Matter Science and Engineering,Key Laboratory of Polymer Chemistry and Physics of Ministry of Education,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China

出　　处：《Chinese Journal of Polymer Science》2022年第5期433-446,共14页高分子科学（英文版）

基　　金：financially supported by the National Key Research and Development Program of China (No. 2019YFA0904203);the National Natural Science Fund for Distinguished Young Scholars (No. 22125101)

摘　　要：Synthetic polypeptides,also known as poly(α-amino acid)s(PαAAs),are biomimetic and biodegradable polymers holding great potential for a variety of biomedical applications.Possessing the same peptide bonds as natural proteins,polypeptides can also adopt typical well-defined secondary structures includingα-helix,which have been shown to significantly impact the physicochemical properties and biological outcomes of materials.In this feature article,we review the state-of-the-art progresses ofα-helical polypeptides for biomedical applications,with a special emphasis on the manipulation of helix-to-coil dynamic transition,conformation-associated anti-biofouling coatings,cellular uptake regulation,and reducing immunogenicity of polypeptide-protein conjugates.Finally,perspectives on outstanding challenges remained in this field and some important future directions are discussed.

关 键 词：Poly(α-amino acid) POLYPEPTIDE HELIX Nonfouling PEPylation 

分 类 号：O629.72[理学—有机化学] R318[理学—化学]