长航疲劳西医发病机制及中医证候特点研究进展  

Research progress on the pathogenesis of western medicine and syndrome characteristics of traditional Chinese medicine on long navigation fatigue

作　　者：杨星哲[1] 李峰 吴凤芝[1] 徐一菲 李杰[1] 戴宁[1] 李丹溪[1] 张蔚 于佳慧 YANG Xing-zhe;LI Feng;WU Feng-zhi;XU Yi-fei;LI Jie;DAI Ning;LI Dan-xi;ZHANG Wei;YU Jia-hui(Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学中医学院

出　　处：《中华中医药杂志》2022年第3期1591-1595,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.81874428)。

摘　　要：长航疲劳常表现为主观疲劳感、不良情绪和认知功能下降。长航疲劳发生率高,研究长航疲劳西医发病机制及中医证候特点具有重要意义。从发病机制、致病特点及临床表现上看,长航疲劳归属于中枢疲劳。现代医学认为,中枢疲劳与下丘脑-垂体-肾上腺轴紊乱、中枢神经系统能量代谢异常、单胺类神经递质如5-羟色胺功能失调、免疫功能异常和神经系统炎症、血管活性肽功能障碍等有关。其中,中枢神经系统奖励-抑制机制失衡及相关环磷酸腺苷信号通路失调是中枢疲劳现代医学发病机制的研究热点。中医认为,疲劳的产生多与肝脾功能失调有关,肝郁脾虚是长航疲劳的中医证候特点,中医药治疗中枢疲劳具有优势。对长航疲劳中医证候特点和西医发病机制进行探究可为中医药治疗长航疲劳提供依据。Subjective fatigue, bad mood and cognitive decline are common manifestations of long navigation fatigue.The incidence of long navigation fatigue is high, and it is of great significance to explore the pathogenesis of western medicine and the syndrome characteristics of traditional Chinese medicine(TCM) of navigation fatigue. Long navigation fatigue is attributed to central fatigue in terms of pathogenesis, pathogenic characteristics and clinical manifestations. Modern medicine believes that central fatigue is related to dysfunction of hypothalamic-pituitary-adrenal axis, abnormal energy metabolism of central nervous system, dysfunction of monoamine neurotransmitters such as serotonin(5-HT), immune dysfunction and dysfunction of nervous system inflammation and vasoactive peptide. Among them, the imbalance of reward-inhibition mechanism of central nervous system and the dysfunction of related cAMP signaling pathway are the research hotspots of modern medical pathogenesis for central fatigue. According to TCM, fatigue is mostly related to stagnation of liver qi and deficiency in the spleen, which is the syndrome characteristic of TCM of long navigation fatigue. TCM has advantages in the treatment of central fatigue. The exploration of syndrome characteristics of TCM and pathogenesis of western medicine on long navigation fatigue can provide a basis for treatment of long navigation fatigue.

关 键 词：长航疲劳 中枢疲劳 环磷酸腺苷信号通路 γ-氨基丁酸/多巴胺平衡机制 肝郁脾虚 

分 类 号：R741[医药卫生—神经病学与精神病学]