TRPV1在器官缺血/再灌注损伤中保护作用的研究进展  

Protective Effect of the Transient Receptor Potential Vanilloid Channel in Ischemic/Reperfusion Injury

作　　者：张文翠 项红兵[1] Zhang Wencui;Xiang Hongbing(Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉科,武汉430030

出　　处：《华中科技大学学报（医学版）》2022年第2期247-253,共7页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.81873467)。

摘　　要：瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1,TRPV1)是一种非选择性阳离子通道,广泛表达于感觉神经纤维和非神经元细胞中,TRPV1的激活参与了多种生理功能的调节。近年来大量研究揭示TRPV1激活可减弱缺血再灌注(ischemic/reperfusion,I/R)引起的心脏、脑、肾、肺、肠等器官的损伤,但目前尚无关于TRPV1的系统性报道。该文主要综述了近年来关于TRPV1及其信号级联在减轻各器官I/R损伤中作用的研究进展。Transient receptor potential vanilloid 1(TRPV1)is a non-selective cationic channel and is widely expressed in sensory nerve fibers and non-neuronal cells.The activation of TRPV1 is involved in the regulation of various physiological functions.In recent years,numerous studies have revealed that TRPV1 activation can attenuate the ischemic/reperfusion(I/R)injury in various organs including the heart,brain,kidney,lung and intestine,but there are no comprehensive reports on TRPV1.This article reviews study findings regarding involvement of TRPV1 and its signal cascade in alleviating organ I/R injury.

关 键 词：瞬时受体电位香草酸亚型1 缺血再灌注损伤 

分 类 号：R363[医药卫生—病理学]