基因工程猪皮的研究进展  

Research progress on skin from genetically engineered pigs

作　　者：李峰[1] 黎君友[2] Li Feng;Li Junyou(Department of Burns and Plastic Surgery,Fourth Medical Center of the Chinese PLA General Hospital,Beijing 100048,China;Trauma Research Center,Fourth Medical Center of the Chinese PLA General Hospital,Beijing 100048,China)

机构地区：[1]解放军总医院第四医学中心烧伤整形医学部,北京100048 [2]解放军总医院第四医学中心创伤研究中心,北京100048

出　　处：《中华损伤与修复杂志（电子版）》2022年第2期163-166,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：科技部国家重点研发计划(2017YFD0501606)。

摘　　要：采用异体皮(或异种皮)覆盖烧伤创面是大面积烧伤治疗的关键措施之一。在异体皮不易获得的情况下,采用异种皮特别是猪皮临时覆盖创面也可以起到一定的治疗作用。但由于种属间的免疫屏障,普通猪皮在人体创面上覆盖时间短、与创面之间不能建立血管网络,其治疗作用远逊于异体皮。近年来通过基因工程对供体猪进行基因改造,包括基因敲除与基因转入,可在一定程度上降低人体对移植物的排斥反应,延长异种皮片的存活时间。本文就用于异种移植的基因工程猪皮的相关研究进展进行综述。The use of allogeneic skin(or xeno-skin)to cover the burn wound is one of the key measure for extensive burn treatment.When allogeneic skin is not easy to obtain,temporary covering of the wound with xenograft of skin,especially pig skin,can also play a certain therapeutic effect.Due to the immune barrier between species,ordinary pig skin covers the human wound for a short time and cannot form vascularization with the wound.In recent years,genetic modification of donor pigs through genetic engineering,including gene knockout and gene transfer,can reduce the rejection of transplants by the human to a certain extent and prolong the survival time of xenografts.This article reviews the research progress of genetically engineered pig skin for xenotransplantation.

关 键 词：皮肤移植 猪 异种移植 基因工程 

分 类 号：TS2[轻工技术与工程—食品科学与工程]