72例结肠癌伴肠梗阻术后切口感染患者浅部脓性分泌物病原菌分布特征及耐药性分析  

Etiology and Drug Resistance of superficial purulent Secretions in 72 Patients with Colon Cancer and intestinal Obstruction with postoperative incision infection

作　　者：吴晓鹏 WU Xiaopeng(Department of Laboratory Medicine,People’s Hospital of Henan University of Traditional Chinese Medicine/Zhengzhou People’s Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]河南中医药大学人民医院,郑州人民医院检验科,河南郑州450000

出　　处：《临床研究》2022年第4期17-20,共4页Clinical Research

摘　　要：目的分析结肠癌伴肠梗阻术后切口感染患者浅部脓性分泌物病原菌分布特征及耐药性,为抗生素合理应用提供依据。方法选取郑州人民医院2019年3月至2020年5月期间接收的结肠癌伴梗阻术后切口感染患者72例,收集全部研究对象浅部脓性分泌物标本予以病原菌培养与药敏试验,分析病原菌分布特征及耐药性。结果72份标本中共分离病原菌174株,其中革兰氏阴性菌109株,占比62.64%,革兰氏阳性菌50株,占比28.74%,真菌15株,占比8.62%;大肠埃希菌对阿莫西林、氨苄西林、头孢噻吩、头孢呋辛、头孢唑啉耐药性高;铜绿假单胞菌对于阿莫西林、氨苄西林、头孢噻吩、头孢呋辛、头孢曲松、头孢唑啉耐药性完全耐药;金黄色葡萄球菌对于阿莫西林、阿奇霉素耐药性高,均超出95%。结论结肠癌伴肠梗阻术后切口感染患者浅部脓性分泌物标本中病原菌具有多样性,且不同病原菌耐药性不同,应在病原菌培养及药敏试验结果指导下选用抗生素,以确保抗生素合理应用。Objective To analyze the pathogenic bacteria and drug susceptibility test results of superficial purulent secretions in patients with colon cancer complicated with intestinal obstruction postoperative incision infection,so as to provide a basis for rational application of antibiotics.Methods A total of 72 patients with colon cancer complicated with postoperative incision infection who were admitted to Zhengzhou people’s hospital from March 2019 to May 2020 were selected,and the superficial purulent secretions of all subjects were collected for pathogen culture and drug susceptibility,the distribution characteristics and drug resistance of pathogenic bacteria were analyzed.Results A total of 174 strains of pathogenic bacteria were isolated from 72 specimens,including 109 strains of gram-negative bacteria,accounting for 62.64%(109/174),50 strains of gram-positive bacteria,accounting for 28.74%(50/174),and 15 strains of fungi,accounting for 8.62%(15/174);Escherichia coli was highly resistant to amoxicillin,ampicillin,cefotaxime,cefuroxime,and cefazolin.Pseudomonas aeruginosa was completely resistant to amoxicillin,ampicillin,cefotaxime,cefuroxime,ceftriaxone,and cefazolin.Staphylococcus aureus was highly resistant to amoxicillin and azithromycin,all exceeding 95%.Conclusion The pathogenic bacteria in the superficial purulent secretions of patients with colon cancer complicated with intestinal obstruction postoperative incision infection are diverse,and the drug resistance of different pathogens is different.Antibiotics should be selected under the guidance of the results of pathogen culture and drug sensitivity test to ensure the rational use of antibiotics.

关 键 词：结肠癌伴肠梗阻 切口感染 浅部脓性分泌物 病原菌培养 药敏试验 

分 类 号：R735.35[医药卫生—肿瘤]