脑血疏口服液对脑室出血患者CRP、Hcy、LpPLA2水平、氧化应激及脑微循环的影响  

Effects of Naoxueshu oral liquid on CRP,Hcy,LpPLA2 levels,oxidative stress and cerebral microcirculation in patients with intraventricular hemorrhage

作　　者：张向前[1] 孙文栋[1] 马新蕾[1] 张磊[1] 佟建洲[1] ZHANG Xiang-qian;SUN Wen-dong;MA Xin-lei;ZHANG Lei;TONG Jian-zhou(Department of Neurosurgery II,West Hospital,Baoding First Central Hospital,Baoding 071000,Hebei,China)

机构地区：[1]保定市第一中心医院西院神经外二科,河北保定071000

出　　处：《川北医学院学报》2022年第4期442-446,共5页Journal of North Sichuan Medical College

基　　金：河北省保定市科技计划项目(2041zf101)。

摘　　要：目的:分析脑血疏口服液对脑室出血患者C反应蛋白(CRP)、同型半胱氨酸(Hcy)、脂蛋白相关磷脂酶A2(LpPLA2)水平、氧化应激及脑微循环的影响。方法:按照治疗方式不同将80例脑室出血患者分为脑血疏组和对照组,每组各40例。对照组给予脑出血后常规治疗,脑血疏组在对照组的基础上给予鼻饲或口服脑血疏口服液。比较两组患者治疗后临床疗效,及治疗前后神经功能、血清CRP、Hcy、LpPLA2水平、氧化应激[超氧化物歧化酶(SOD)、丙二醛(MDA)、过氧化氢酶(CAT)]及脑微循环[血小板计数(PLT)、纤维蛋白原(Fib)、血小板聚集率(PAG)]水平变化。结果:治疗后,两组NIHSS评分、CSS评分均较治疗前降低(P<0.05),且脑血疏组低于对照组(P<0.05)。治疗后,两组血清CRP、Hcy、LpPLA2水平均较治疗前降低(P<0.05),且脑血疏组低于对照组(P<0.05);两组血清SOD、CAT水平均较治疗前升高,MDA较治疗前降低(P<0.05),且脑血疏组的改善程度优于对照组(P<0.05);两组血清PLT、Fib、PAG水平均较治疗前降低(P<0.05),且脑血疏组低于对照组(P<0.05)。脑血疏组临床总有效率高于对照组(92.50%vs.77.50%,P<0.05)。结论:脑血疏口服液治疗脑室出血患者的临床疗效较显著,可明显减轻患者炎症反应、氧化应激反应,促进患者神经功能及脑血液微循环功能恢复。Objective:To analyze the effects of Naoxueshu oral liquid on C-reactive protein(CRP),homocysteine(Hcy),lipoprotein associated phospholipase A2(LpPLA2),oxidative stress and cerebral microcirculation in patients with intraventricular hemorrhage.Methods:80 patients with intraventricular hemorrhage were divided into Naoxueshu group and control group according to different treatment methods,40 cases in each group.The patients in the control group were given routine treatment after intracerebral hemorrhage,and the Naoxueshu group was given nasal feeding or oral Naoxueshu oral liquid on this basis.The clinical effects of the two groups were compared,as well as the changes of neurological function,serum CRP,Hcy,LpPLA2 levels,oxidative stress[superoxide dismutase(SOD),malondialdehyde(MDA),catalase(CAT)]and cerebral microcirculation[platelet count(PLT),fibrinogen(FIB),platelet aggregation rate(PAG)]before and after treatment.Results:After treatment,the NIHSS score and CSS score of the two groups were significantly lower than those before treatment(P<0.05),and the Naoxueshu group was significantly lower than the control group(P<0.05).After treatment,the levels of serum CRP,Hcy and LpPLA2 in the two groups were significantly lower than those before treatment(P<0.05),and those in the Naoxueshu group were significantly lower than those in the control group(P<0.05).After treatment,the levels of serum SOD and CAT in the two groups were significantly higher than those before treatment,and MDA was significantly lower than those before treatment(P<0.05).The improvement of the above indexes in Naoxueshu group was significantly better than that in the control group(P<0.05).After treatment,the levels of serum PLT,Fib and PAG in the two groups were significantly lower than those before treatment(P<0.05),and the level of Naoxueshu group was significantly lower than that in the control group(P<0.05).The total effective rate of Naoxueshu group was 92.50%,which was significantly higher than 77.50% of the control group(P<0.05).Conclusion:Na

关 键 词：脑室出血 脑血疏口服液 CRP HCY LpPLA2 氧化应激 脑微循环 

分 类 号：R743.34[医药卫生—神经病学与精神病学]