宫颈疾病患者p16/Ki-67表达状况及其与HPV感染的相关性  

Expression of p16/Ki-67 in patients with cervical diseases and its correlation with HPV infection

作　　者：崔焱 张瑜英 潘琳 CUI Yan;ZHANG Yu-ying;PAN Lin(Department of Gynecology,Beijing Hepingli Hospital,Beijing 100013,China)

机构地区：[1]北京和平里医院妇科,北京100013

出　　处：《川北医学院学报》2022年第4期494-496,500,共4页Journal of North Sichuan Medical College

摘　　要：目的:分析宫颈疾病患者p16/Ki-67表达状况及其与人乳头状瘤病毒(HPV)感染的相关性。方法:选取150例宫颈疾病患者为研究对象,按照病理类型分为宫颈癌组(n=20)、高度鳞状上皮内病变(HSIL)组(n=35)、低度鳞状上皮内病变(LSIL)组(n=45)和宫颈炎组(n=50)。比较四组患者p16/Ki-67双染阳性率及HPV感染率;分析p16/Ki-67阳性表达与HPV感染的相关性。结果:四组患者P16/Ki67双染阳性率及HPV感染率比较,差异有统计学意义(P<0.05),其中宫颈炎组低于宫颈癌组、HSIL组及LSIL组(P<0.05);LSIL组低于宫颈癌组及HSIL组(P<0.05);HSIL组与宫颈癌组比较,差异无统计学意义(P>0.05)。p16/Ki-67阳性表达与HPV感染呈正相关(r=0.420,P<0.05)。p16/Ki-67双染阳性患者病变发生率高于双染阴性患者(35.7%vs.6.5%),差异有统计学意义(χ^(2)=6.287,P=0.012)。结论:p16/Ki-67表达与HPV感染呈正相关,临床应用p16/Ki-67双染检测可有效评估宫颈病变,预测LSIL转归。Objective:To analyze the expression of p16/Ki-67 in patients with cervical diseases and its correlation with human papillomavirus(HPV)infection.Methods:150 patients with cervical diseases were selected as the research objects.They were divided into cervical cancer group(n=20),high-grade squamous intraepithelial lesion(HSIL)group(n=35),low-grade squamous intraepithelial lesion(LSIL)group(n=45)and cervicitis group(n=50).The difference of p16/Ki-67 double staining positive rate and HPV infection rate in four groups and the correlation between p16/Ki-67 positive expression and HPV infection were observed.Results:The positive rate of p16/Ki67 double staining and HPV infection rate among the four groups were statistically significant(P<0.05).The positive rate of p16/Ki67 double staining and HPV infection rate in cervicitis group were significantly lower than those in cervical cancer group,HSIL group and LSIL group(P<0.05),the LSIL group were significantly lower than the cervical cancer group and HSIL group(P<0.05).There was no significant difference in p16/Ki67 double staining positive rate and HPV infection rate between HSIL group and cervical cancer group(P>0.05).The positive expression of p16/Ki-67 was positively correlated with HPV infection(r=0.420,P<0.05).The incidence of lesions in patients with positive p16/Ki-67 double staining was 35.7%,which was significantly higher than that in patients with negative p16/Ki-67 double staining(6.5%),the difference was statistically significant(χ^(2)=6.287,P=0.012).Conclusion:The expression of p16/Ki-67 is positively correlated with HPV infection.The clinical application of p16/Ki-67 double staining can effectively evaluate cervical lesions and predict the outcome of LSIL.

关 键 词：HR-HPV阳性感染 低度鳞状上皮内病变 高度鳞状上皮内病变 宫颈癌 宫颈炎 p16/Ki-67双染阳性率 

分 类 号：R737.3[医药卫生—肿瘤]