替硝唑联合阿莫西林治疗急性肠胃炎患者的临床效果  

Clinical Effect of Tinidazole Combined with Amoxicillin in the Treatment of Acute Gastroenteritis

作　　者：隋泰北 SUI Taibei(Jinzhou Second Hospital,Jinzhou 121000,China)

机构地区：[1]锦州市第二医院,辽宁锦州121000

出　　处：《中国医药指南》2022年第11期25-28,共4页Guide of China Medicine

摘　　要：目的 对急性肠胃炎患者采取替硝唑联合阿莫西林治疗,分析药物治疗干预后的效果。方法 将在2019年1月至2020年1月本院收治的急性肠胃炎患者160例,采用随机分组法分为两组,对照组80例采用阿莫西林进行治疗,试验组80例采用替硝唑联合阿莫西林进行治疗。对比两组患者的治疗总有效率、不良反应发生情况以及用药满意度,观察两组的血清炎性因子。结果 试验组经替硝唑+阿莫西林治疗后,其临床疗效与满意度均高于对照组(P <0.05)。在不良反应发生率上,两组对比差异无统计学意义(P> 0.05)。在症状缓解时间与住院时间上,试验组均短于对照组(P <0.05)。在躯体功能、日常生活能力、心理健康以及社会功能评分上,试验组显著高于对照组(P <0.05)。在血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)上,试验组低于对照组(P <0.05)。结论 针对发生急性肠胃炎的患者采用替硝唑联合阿莫西林进行治疗,对改善患者的临床症状具有促进作用,有利于减轻患者的炎性反应,提升患者的生存质量,且不良反应较少,用药满意度高,符合医院高质量治疗工作的发展方向。Objective The patients with acute gastroenteritis were treated with tinidazole combined with amoxicillin, and the effect of drug treatment intervention was analyzed. Methods A total of 160 patients with acute gastroenteritis admitted to our hospital from January 2019 to January 2020 were randomly divided into two groups, 80 patients were treated with amoxicillin as the control group, 80 cases were treated with tinidazole and amoxicillin as the experimental group. The total treatment efficiency, adverse reactions and drug satisfaction of the two groups were compared. Serum inflammatory factors in the two groups were observed. Results After treatment with tinidazole + amoxicillin, the clinical efficacy and satisfaction of the experimental group were higher than those of the control group(P<0.05). There was no significant difference between the two groups in the incidence of adverse reactions(P>0.05). The days of symptom relief and hospital stay in the experimental group were shorter than those in the control group(P<0.05). The scores of physical function, daily living ability, mental health and social function in the experimental group were significantly higher than those in the control group(P<0.05). In serum interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α) and C-reactive protein(CRP), the experimental group was lower than the control group( P<0.05).Conclusion For patients with acute gastroenteritis, the combination of tinidazole and amoxicillin can promote the improvement of the clinical symptoms of the patients, help reduce the inflammatory response of the patients, improve the quality of life of the patients, and has fewer adverse reactions, and the medication is satisfactory. High degree of treatment, in line with the development direction of the hospital’s high-quality treatment work.

关 键 词：急性肠胃炎 替硝唑 阿莫西林 不良反应 用药满意度 联合治疗 

分 类 号：R573.3[医药卫生—消化系统]