艾迪注射液对人肝癌细胞的增殖抑制作用和凋亡诱导活性  

Proliferation-inhibitory effect and apoptosis-inducing activity of Aidi injection in human hepatocellular carcinoma cells

作　　者：唐静[1] 王国俊 TANG Jing;WANG Guojun(Department of Pharmacy,the First People's Hospital of Neijiang,Sichuan Province,Neijiang 641000,China;不详)

机构地区：[1]四川省内江市第一人民医院药剂科,641000 [2]西南医科大学附属医院药学部,四川省泸州市646000

出　　处：《临床合理用药杂志》2022年第10期30-33,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察艾迪注射液对肝癌细胞株Hep3B和LM3的体外抗肿瘤作用。方法通过细胞的活力测定(MTS)法测定不同浓度艾迪注射液对Hep3B和LM3肝癌细胞的增殖抑制作用,流式细胞术分析不同浓度艾迪注射液对Hep3B和LM3肝癌细胞的诱导凋亡活性。结果艾迪注射液可显著抑制Hep3B和LM3肝癌细胞的增殖,并可有效诱导Hep3B和LM3肝癌细胞凋亡。结论艾迪注射液可有效抑制肝癌细胞增殖并诱导肝癌细胞凋亡,可能是艾迪注射液治疗肝癌发挥抗肿瘤疗效的重要机制。Objective To observe the vitro antitumor effects of Aidi injection on hepatocellular carcinoma cells lines Hep3B and LM3.Methods MTS assay was performed to measure the cell proliferation-inhibitory effects of Aidi injection at different concentrations on hepatocellular carcinoma cells Hep3B and LM3,flow cytometry was used to analyze the apoptosis-inducing activity of Aidi injection at different concentrations in hepatocellular carcinoma cells Hep3B and LM3.Results Aidi injection could significantly inhibit the proliferation of Hep3B and LM3 cells,and could effectively induce apoptosis in Hep3B and LM3 cells.Conclusion Aidi injection can effectively inhibit cell proliferation and induce apoptosis in Hep3B and LM3 cells,which may be an important mechanism for therapeutic efficacy of Aidi injection in the treatment of hepatocellular carcinoma.

关 键 词：肝癌 艾迪注射液 细胞增殖抑制作用 凋亡诱导活性 抗肿瘤作用 

分 类 号：R735.7[医药卫生—肿瘤]