Sodium selenite promotes neurological function recovery after spinal cord injury by inhibiting ferroptosis  

作　　者：Yi-Xin Chen Talifu Zuliyaer Bin Liu Shuang Guo De-Gang Yang Feng Gao Yan Yu Ming-Liang Yang Liang-Jie Du Jian-Jun Li 

机构地区：[1]School of Rehabilitation Medicine,Capital Medical University,Beijing,China [2]China Rehabilitation Science Institute,Beijing,China [3]Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing,China [4]Department of Spinal and Neural Functional Reconstruction,China Rehabilitation Research Center,Beijing,China [5]Beijing Key Laboratory of Neural Injury and Rehabilitation,Beijing,China [6]Department of Rehabilitation Medicine,Xiangya Hospital of Central South University,Changsha,Hunan Province,China [7]Department of Spine Surgery,Hunan Provincial People’s Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha,Hunan Province,China

出　　处：《Neural Regeneration Research》2022年第12期2702-2709,共8页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China, No.81870979(to JJL);the Scientific Research Foundation of China Rehabilitation Research Center, No.2020-02(to JJL);the Natural Science Foundation of Changsha, No.kq2014285(to YXC)

摘　　要：Ferroptosis is a recently discovered form of iron-dependent cell death,which occurs during the pathological process of various central nervous system diseases or injuries,including secondary spinal cord injury.Selenium has been shown to promote neurological function recovery after cerebral hemorrhage by inhibiting ferroptosis.However,whether selenium can promote neurological function recovery after spinal cord injury as well as the underlying mechanism remain poorly understood.In this study,we injected sodium selenite(3μL,2.5μM)into the injury site of a rat model of T10 vertebral contusion injury 10 minutes after spinal cord injury modeling.We found that sodium selenite treatment greatly decreased iron concentration and levels of the lipid peroxidation products malondialdehyde and 4-hydroxynonenal.Furthermore,sodium selenite increased the protein and mRNA expression of specificity protein 1 and glutathione peroxidase 4,promoted the survival of neurons and oligodendrocytes,inhibited the proliferation of astrocytes,and promoted the recovery of locomotive function of rats with spinal cord injury.These findings suggest that sodium selenite can improve the locomotive function of rats with spinal cord injury possibly through the inhibition of ferroptosis via the specificity protein 1/glutathione peroxidase 4 pathway.

关 键 词：ferroptosis glutathione peroxidase 4 GLUTATHIONE IRON lipid peroxidation neural regeneration secondary injury sodium selenite specificity protein 1 spinal cord injury 

分 类 号：R651.2[医药卫生—外科学] R-332[医药卫生—临床医学]