心脏标志物检测在肾脏功能不全患者中的应用价值观察  

Observation on the Application Value of Cardiac Marker Detection in Patients with Renal Insufficiency

作　　者：何雯 柴玲[1] 刘荣均[1] 唐芸[1] HE Wen;CHAI Ling;LIU Rongjun;TANG Yun(Department of Laboratory Medicine,Kunming Hospital of Traditional Chinese Medicine,Kunming,Yunnan Province,650011 China)

机构地区：[1]昆明市中医医院检验科,云南昆明650011

出　　处：《系统医学》2022年第2期14-16,24,共4页Systems Medicine

基　　金：血清中铜、铁、锌含量与中医血虚证和气虚证的相关性研究。

摘　　要：目的观察在肾脏功能不全患者中检测心脏标志物的价值。方法选取在该院2019年12月—2020年12月就诊的肾脏功能不全者79例患者为观察对象,以肌酐浓度及血尿素水平为依据进行分组,纳入尿毒症组、失代偿组、代偿组,例数分别为31例、25例、23例,另外选取同期健康体检正常者37名,设置为对照组。于各组患者空腹状态下,采集静脉血液,血清分离后,采用电化学发光免疫分析法对B型氨基酸钠尿肽原(NT-proBMP)、肌酸激酶同工酶(CK-MB)、肌红蛋白(MYO)、血清高敏肌钙蛋白(hs-cTnl)检测,对比各组的检测结果。结果对比对照组,3组肌酐和尿素水平、NT-proBNP水平、MYO水平、hs-cTnl水平均显著提升,尤其是尿毒症组,各项指标均最高,分别为肌酐(736.75±298.65)μmol/L、尿素(26.90±8.85)mmol/L、NT-proBNP 1357.3(536.4~4662.8)pg/mL、MYO 115.8(94.3~175.9)ng/mL、hs-cTnl 25.8(16.6~33.9)pg/mL,差异有统计学意义(P<0.05)。4组患者CK-MB检测结果比较差异无统计学意义(P>0.05)。结论肾功能不全极易诱发心血管疾病,对心脏标志物进行早期检测,可有效判断心肌损伤,同时可评估心肌梗死发生风险,预估心衰发生风险。Objective To observe the value of detecting cardiac markers in patients with renal insufficiency.Methods Selected 79 patients with renal insufficiency who were treated in the hospital from December 2019 to December 2020 as the observation objects.The groups were grouped based on the creatinine concentration and blood urea level,and were included in the uremic group,decompensated group,and compensated group,the number of cases were 31,25,and 23 respectively.In addition,37 patients with normal physical examination during the same period were selected as the control group.In the fasting state of each group of patients,venous blood was collected and the serum was separated.Electrochemiluminescence immunoassay was used to detect B-type amino acid natriuretic peptide(NT-proBMP),creatine kinase isoenzyme(CK-MB),myoglobin(MYO),and serum high-sensitivity troponin(hs-cTnl),compare the test results of each group.Results Compared with the control group,the creatinine and urea levels,NT-proBNP levels,MYO levels,and hs-cTnl levels in the three groups increased significantly,especially in the uremic group,with the highest levels of creatinine(736.75±298.65)μmol/L,Urea(26.90±8.85)mmol/L,NT-proBNP 1357.3(536.4-4662.8)pg/mL,MYO 115.8(94.3-175.9)ng/mL,hs-cTnl 25.8(16.6-33.9)pg/mL,the difference was statistically significant(P<0.05).There was no statistically significant difference in CK-MB test results between the 4 groups of patients(P>0.05).Conclusion Renal insufficiency is very prone to cardiovascular disease.Early detection of cardiac markers can effectively judge myocardial damage.At the same time,it can assess the risk of myocardial infarction and estimate the risk of heart failure.

关 键 词：肾功能不全 NT-proBMP CK-MB MYO hs-cTnl 心脏标志物 

分 类 号：R692[医药卫生—泌尿科学]