Group 8–9 Metal‑Based Luminescent Chemosensors for Protein Biomarker Detection  

作　　者：Dik‐Lung Ma Chun Wu Guodong Li Chung‐Hang Leung 

机构地区：[1]Department of Chemistry,Faculty of Science,Hong Kong Baptist University,Kowloon Tong,Hong Kong,China [2]State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Macao,China

出　　处：《Journal of Analysis and Testing》2018年第1期77-89,共13页分析检测（英文）

基　　金：Hong Kong Baptist University(FRG2/16-17/007),the Health and Medical Research Fund(HMRF/14130522,14150561);the Research Grants Council(HKBU/12301115),the National Natural Science Foundation of China(21575121,21775131 and 21628502);the Guangdong Province Natural Science Foundation(2015A030313816);the Hong Kong Baptist University Century Club Sponsorship Scheme 2017,the Interdisciplinary Research Matching Scheme(RC-IRMS/15-16/03);Innovation and Technology Fund(ITS/260/16FX),Collaborative Research Fund(C5026-16G);Matching Proof of Concept Fund(MPCF-001-2017/18);the Science and Technology Development Fund,Macao SAR(098/2014/A2);the University of Macao(MYRG2015-00137-ICMSQRCM,MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS).

摘　　要：The development of transition metal complex-based luminescent chemosensors has recently aroused increasing interest for protein biomarker labelling and detection,especially for the real-time diagnosis and treatment of disease.This is owing to their unique photophysical properties,particularly their long-lived and environmentally sensitive emission,which can be easily controlled via the structural modification of ligands.In this overview,we highlight recent examples of protein biomarker detection using group 8–9 metal-based luminescent chemosensors,including the frequently employed ruthenium(II)and iridium(III)complexes.Various mechanisms and sensing modes are described and compared,and the outlook and future directions of this field are discussed as well.

关 键 词：Chemosensor BIOMARKER Metal complex LUMINESCENCE 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]