脑出血后炎症反应中小胶质细胞及其相关炎症介质的作用研究进展  

Research progress of microglia and related inflammatory mediators in inflammatory response after intracerebral hemorrhage

作　　者：龚举鑫 燕鹏 郑传华 覃成箭[2] 罗起胜[2] GONG Ju-xin;YAN Peng;ZHENG Chuan-hua(Graduate School,Youjiang Medical Unaersite for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院研究生院,百色533000 [2]右江民族医学院附属医院神经外科

出　　处：《临床神经外科杂志》2022年第2期228-231,共4页Journal of Clinical Neurosurgery

基　　金：广西自然科学基金项目(2020JJA140098)。

摘　　要：脑出血(ICH)继发脑损伤发生机制较为复杂,其中血肿周围组织的炎症反应在继发性脑损伤中至关重要。多种细胞及与其相关的炎症介质在ICH后炎症反应中发挥作用。本文主要就小胶质细胞及与其相关的肿瘤坏死因子(TNF)、白细胞介素(IL)、转化生长因子-β(TGF-β)、基质金属蛋白酶(MMPs)等在炎症反应中的主要作用及临床应用做一综述。The mechanism of secondary brain injury in intracerebral hemorrhage(ICH)is more complicated,and the inflammatory response of the tissue around the hematoma is very important in secondary brain injury.Multiple cells and the associated inflammatory media play a role in the inflammatory response after ICH.This article mainly reviews the main role and clinical application of microglia and its related tumor necrosis factors(TNF),interleukin(IL),transforming growth factor beta(TGF-β),matrix metalloproteinases(MMPs)in inflammatory response.

关 键 词：脑出血 小胶质细胞 肿瘤坏死因子 白细胞介素 转化生长因子-Β 基质金属蛋白酶 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R651[医药卫生—临床医学]