双相障碍Ⅱ型患者认知功能探讨  

Discussion on Cognitive Function of Patients with Bipolar Disorder Type Ⅱ

作　　者：何建军 冯杏 HE Jianjun;FENG Xing(Department of psychiatry,Maoming Third People's Hospital,Maoming,Guangdong Province,525200 China)

机构地区：[1]茂名市第三人民医院精神科,广东茂名525200

出　　处：《中外医疗》2022年第3期1-4,共4页China & Foreign Medical Treatment

基　　金：茂名市科技计划项目(2019226)。

摘　　要：目的探讨双相障碍Ⅱ型抑郁发作患者认知功能。方法随机选取2020年1月—2021年1月该院收治的双相障碍Ⅱ型抑郁发作患者40例,同时选取40名健康者作为对照组,所有患者均接受精神分裂症认知功能评估成套测验对患者认知功能进行检验,并对比两组HAMD24评分。结果双相障碍Ⅱ型抑郁发作患者认知功能评分中词语学习(46.22±9.02)分、工作记忆(45.85±9.34)分、视觉学习(46.34±10.04)分、注意警觉性(43.38±8.13)分、信息处理速度(47.35±8.67)分、推理与问题解决(45.34±8.13)分、社会认知(43.17±9.24)分7个维度评分均明显少于健康者的认知功能评分,差异有统计学意义(t=3.815、2.888、2.244、5.003、3.012、4.444、4.705,P<0.05);双相障碍Ⅱ型抑郁发作患者HAMD24评分(26.12±5.03)分明显高于健康者,差异有统计学意义(t=27.990,P<0.05);双相障碍Ⅱ型抑郁发作患者的BRMS评分(26.85±3.45)分与PANSS评分(65.52±8.42)分明显高于健康者,差异有统计学意义(t=24.049、17.863,P<0.05);双相障碍Ⅱ型抑郁发作患者IL-1β水平(4.38±0.75)ng/L,IL-4水平(3.58±0.63)ng/L,TNF-α水平(10.66±1.88)ng/L明显高于健康者,差异有统计学意义(t=19.468、15.340、13.560,P<0.05)。结论双相障碍Ⅱ型抑郁发作患者存在多方面的认知功能障碍,随着发作次数的增加,其词语学习、工作记忆、推理与问题解决等能力越来越差,应给予双相障碍Ⅱ型抑郁发作患者认知功能方面的高度重视。Objective To explore the cognitive function of patients with bipolar disorder type Ⅱ depressive episode.Methods 40 patients with bipolar disorder type Ⅱ depressive episodes admitted to the hospital from January 2020 to January 2021 were randomly selected.At the same time,40 healthy people were selected as the control group.All patients received a set of schizophrenia cognitive function assessment tests to test the cognitive function of the patients,and compared the two groups of HAMD24 scores.Results The scores of seven dimensions in the cognitive function scores of patients with bipolar disorder type Ⅱ depression in word learning(46.22±9.02)points,working memory(45.85±9.34)points,visual learning(46.34±10.04)points,attentional alertness(43.38±8.13)points,information processing speed(47.35±8.67)points,reasoning and problem solving(45.34±8.13)points,and social cognition(43.17±9.24)points were significantly lower than those of healthy people,the difference was statistically significant(t=3.815,2.888,2.244,5.003,3.012,4.444,4.705,P<0.05);the HAMD24 score of patients with bipolar disorder type Ⅱ depressive episode(26.12±5.03)points was significantly higher than that of healthy people,and the difference was statistically significant(t=27.990,P<0.05).The BRMS score(26.85±3.45)points and PANSS score(65.52±8.42)points of patients with bipolar disorder type Ⅱ depression were significantly higher than those of healthy people,and the differences were statistically significant(t=24.049,17.863,P<0.05).The levels of IL-1β(4.38±0.75)ng/L,IL-4(3.58±0.63)ng/L and TNF-α(10.66±1.88)ng/L in patients with bipolar disorder typeⅡdepression were significantly higher than those in healthy people,the difference was statistically significant(t=19.468,15.340,13.560,P<0.05).Conclusion Patients with bipolar disorder type Ⅱ depressive episodes have various cognitive dysfunctions.As the number of episodes increases,her ability to learn vocabulary,working memory,reasoning,and problem solving gets worse and worse.Great

关 键 词：双相障碍Ⅱ型 抑郁 认知功能 MCCB认知检测 

分 类 号：R749[医药卫生—神经病学与精神病学]