成年健康体检人群幽门螺旋杆菌感染与超重/肥胖、血脂、血糖及非酒精性脂肪肝的关系研究  

Analysis of correlation between the helicobacter pylori infection and overweight/obesity, blood lipids, blood glucose and NAFLD among adult health examination population

作　　者：丰萍璐 刘若男 李坤[1] 秦克秀[1] 李家斌[2] 许夕海[1] FENG Ping-lu;LIU Ruo-nan;LI Kun;QIN Ke-xiu;LI Jia-bin;XU Xi-hai(Health Management Center,First Affiliaied,Hospital of Anhui Medical University,Hefei,Anhui 230022,China;不详)

机构地区：[1]安徽医科大学第一附属医院健康管理中心,安徽合肥230022 [2]安徽医科大学第一附属医院感染病科,安徽合肥230022

出　　处：《现代预防医学》2022年第8期1375-1378,共4页Modern Preventive Medicine

摘　　要：目的 了解安徽地区成年健康体检人群幽门螺旋杆菌(Helicobacter pylori, Hp)的感染现状,分析Hp感染与超重/肥胖、血脂、血糖及非酒精性脂肪肝(non-alcoholicfatty liverdisease, NAFLD)的关系。方法 在2020年1—12月安徽医科大学第一附属医院健康管理中心的成年健康体检人群中,选取13C/14C呼气试验、一般检查、生化及肝脏超声等体检资料齐全的33 050例为研究对象。根据呼气试验结果分为Hp阳性组和Hp阴性组。使用二元logistic回归分析Hp感染与超重/肥胖、血脂异常、高血糖、NAFLD的关系。结果 Hp感染率随着BMI的上升逐渐增高,其中肥胖(BMI>28kg/m2)人群Hp感染率最高。NAFLD组Hp感染率38.17%(4 570/11 972)高于非脂肪肝组36.64%(7 723/21 078),差异有统计学意义(χ^(2)=7.674,P<0.05)。Hp阳性组的BMI、TC、TG、LDL-C及空腹血糖水平高于Hp阴性组,HDL-C水平低于Hp阴性组,差异有统计学意义(t值分别为-61.945、-5.227、-4.137、-6.088、-5.981、5.257,P<0.05)。多因素二元logistic回归分析显示,肥胖、低HDL-C血症、高LDL-C血症、高血糖是Hp感染的危险因素,OR值分别为1.136(95%CI:1.049~1.231)、1.104(95%CI:1.029~1.184)、1.252(95%CI:1.083~1.448)、1.099(95%CI:1.027~1.177)。结论成年健康体检人群幽门螺旋杆菌感染率随着BMI的增加呈上升趋势,肥胖、低HDL血症、高LDL血症、高血糖是Hp感染的危险因素。Objective To investigate the infection status of Helicobacter pylori(Hp) among physical examination population in Anhui, and to explore the association between Hp infection and overweight/obesity, blood lipids, blood glucose, and non-alcoholic fatty liver disease(NAFLD). Methods From January 2020 to December 2020, 33 050 cases with complete physical examination data including 13C/14C breath test, general examination, biochemistry and liver ultrasound were selected from the adult health check-up population in the Health Management Center of the First Affiliated Hospital of Anhui Medical University. According to the results of the breath test, they were divided into Hp-positive and Hp-negative groups. The relationship between Hp infection and overweight/obesity, dyslipidemia, hyperglycemia, and NAFLD was analyzed using binary logistic regression. Results Hp infection rate increased gradually with the rise of BMI, with the highest Hp infection rate in the obese(BMI>28 kg/m2) group. 38.17%(4,570/11 972) of the NAFLD group had higher Hp infection rate than 36.64%(7 723/21 078) of the non-fatty liver group, and the difference was statistically significant(χ^(2)=7.674, P<0.05). The BMI, TC,TG, LDL-C and fasting glucose levels were higher in the positive group than in the Hp-negative group, and HDL-C levels were lower than in the Hp-negative group, with statistically significant differences(t=-61.945,-5.227,-4.137,-6.088,-5.981, and 5.257, respectively, P <0.05). Multifactorial binary logistic regression analysis showed that obesity, low HDL-Cemia, high LDL-Cemia, and hyperglycemia were risk factors for Hp infection with ORs of 1.136(95% CI: 1.049 to 1.231),1.104(95%CI: 1.029 to 1.184), 1.252(95%CI: 1.083 to 1.448), and 1.099(95%CI: 1.027 to 1.177). Conclusion The prevalence of Hp infection in adult health check-up population showed an increasing trend with increasing BMI, and obesity, low HDLCemia, high LDL-Cemia, and hyperglycemia were risk factors for Hp infection.

关 键 词：幽门螺旋杆菌 肥胖 血脂 血糖 非酒精性脂肪肝 

分 类 号：R573.6[医药卫生—消化系统]