Hp感染性胃溃疡患者血清炎症因子、MMP-9和TIMP-1水平变化及其与炎性活动度的相关性  

Changes of serum inflammatory factors,MMP-9,and TIMP-1 in patients with Helicobacter pylori-infected gastric ulcer and their correlation with inflammatory activity

作　　者：袁浩壬 付晓林 YUAN Hao-ren;FU Xiao-lin(Department of Gastroenterology,the General Hospital of Angang Group Company,Anshan 114002,Liaoning,CHINA)

机构地区：[1]鞍钢集团公司总医院消化内科,辽宁鞍山114002

出　　处：《海南医学》2022年第8期968-971,共4页Hainan Medical Journal

摘　　要：目的观察幽门螺杆菌(Hp)感染性胃溃疡患者血清炎症因子、外周血基质金属蛋白酶-9(MMP-9)和组织金属蛋白酶抑制剂-1(TIMP-1)水平变化,并探讨其与炎性活动度的相关性。方法回顾性分析2020年2月至2021年3月鞍钢集团公司总医院收治的140例胃溃疡患者的临床资料,根据Hp感染情况将Hp感染性胃溃疡患者设为观察组(n=80),非Hp感染性胃溃疡患者设为对照组(n=60)。比较两组患者的血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、MMP-9、TIMP-1的水平及炎性活动度,采用Spearman分析Hp感染性胃溃疡患者TNF-α、IL-8、MMP-9、TIMP-1与炎性活动度的相关性。结果观察组患者的TNF-α、IL-8、MMP-9、TIMP-1水平分别为(298.12±32.15)pg/L、(39.12±4.18)pg/L、(187.32±20.15)ng/L、(281.13±19.71)ng/L,明显高于对照组的(157.68±31.02)pg/L、(25.47±6.02)pg/L、(110.71±15.79)ng/L、(182.17±24.71)ng/L,差异均有统计学意义(P<0.05);两组患者的炎性活动度比较差异有统计学意义(P<0.05);重度Hp感染性胃溃疡患者TNF-α、IL-8、MMP-9、TIMP-1水平[(331.71±32.79)pg/L、(49.21±3.22)pg/L、(231.74±22.71)ng/L、(309.28±24.02)ng/L]高于中度患者[(259.13±24.18)pg/L、(38.12±3.02)pg/L、(189.32±19.27)ng/L、(287.14±22.71)ng/L]和轻度患者[(203.19±19.32)pg/L、(23.17±2.15)pg/L、(154.37±15.47)ng/L、(251.13±20.17)ng/L],且中度患者高于轻度患者,差异均有统计学意义(P<0.05);Spearman相关性分析结果显示:TNF-α、IL-8、MMP-9、TIMP-1水平均与炎性活动性呈正相关(r=0.771、0.864、0.397、0.419,P<0.05)。结论Hp感染性胃溃疡患者的炎症因子、MMP-9、TIMP-1水平明显升高,且与炎性活动度密切相关,通过监测四者水平有利于把握患者炎性活动度,具有较高的临床应用价值。Objective To observe the changes of serum inflammatory factors,peripheral blood matrix metallo-proteinase-9(MMP-9),and tissue metalloproteinase inhibitor-1(TIMP-1)in patients with Helicobacter pylori(HP)-in-fected gastric ulcer,and to explore their correlation with inflammatory activity.Methods A total of 140 patients with gastric ulcer treated in the General Hospital of Angang Group Company from February 2020 to March 2021 were ana-lyzed retrospectively.According to the situation of HP infection,the patients with HP-infected gastric ulcer were selected as the observation group(n=80),and the patients without HP-infected gastric ulcer were enrolled as the control group(n=60).The serum tumor necrosis factors-α(TNF-α),the levels of interleukin-8(IL-8),MMP-9,TIMP-1,and inflamma-tory activity were compared between the two groups.The correlation between TNF-α,IL-8,MMP-9,TIMP-1 and in-flammatory activity were analyzed by Spearman.Results The levels of TNF-α,IL-8,MMP-9,and TIMP-1 in the ob-servation group were(298.12±32.15)pg/L,(39.12±4.18)pg/L,(187.32±20.15)ng/L,and(281.13±19.71)ng/L,which were significantly higher than(157.68±31.02)pg/L,(25.47±6.02)pg/L,(110.71±15.79)ng/L,and(182.17±24.71)ng/L in the control group(P<0.05).There was significant difference in inflammatory activity between the two groups(P<0.05).The levels of TNF-α,IL-8,MMP-9,TIMP-1 in patients with severe HP-infected gastric ulcer were(331.71±32.79)pg/L,(49.21±3.22)pg/L,(231.74±22.71)ng/L,(309.28±24.02)ng/L,which were significantly higher(259.13±24.18)pg/L,(38.12±3.02)pg/L,(189.32±19.27)ng/L,(287.14±22.71)ng/L in patients with moderate HP-infected gas-tric ulcer and(203.19±19.32)pg/L,(23.17±2.15)pg/L,(154.37±15.47)ng/L,(251.13±20.17)ng/L in patients with mild HP-infected gastric ulcer(P<0.05);the levels in patients with moderate HP-infected gastric ulcer were significantly high-er than those in patients with mild HP-infected gastric ulcer(P<0.05).Spearman correlation analysis showed that the lev-els of TNF-α,IL-8,MMP-9,and TIMP-

关 键 词：幽门螺杆菌 胃溃疡 肿瘤坏死因子-α 白细胞介素-8 炎性活动度 组织金属蛋白酶抑制剂-1 基质金属蛋白酶-9 相关性 

分 类 号：R573.1[医药卫生—消化系统]