徐州地区癫痫发病和抗癫痫药物使用情况的回顾性分析  

Etiologic features and utilization of antiepileptic drugs in people with epilepsy in Xuzhou:a retrospective study

作　　者：王忠诚 张玉东 胡献礼[3] 刘超侠 WANG Zhongcheng;ZHANG Yudong;HU Xianli;LIU Chaoxia(Department of Pathophysiology,School of Basic Medicine,Xuzhou Medical University,Xuzhou,Jiangsu 221004,China;General Laboratory of Surgery,Xuzhou Medical University;Emergency Center,Xuzhou Central Hospital,Xuzhou,Jiangsu 221009)

机构地区：[1]徐州医科大学基础医学院病理生理学教研室,江苏徐州221004 [2]徐州医科大学外科总实验室 [3]徐州市中心医院急诊科,江苏徐州221009

出　　处：《徐州医科大学学报》2022年第3期175-180,共6页Journal of Xuzhou Medical University

基　　金：国家自然科学基金(81801168)。

摘　　要：目的评估徐州市癫痫发病特点及抗癫痫药物的使用特点。方法选取2017年12月—2019年12月于徐州市中心医院就诊的癫痫患者。通过问卷调查和病历复核采集临床资料。结果本研究共募集199例患者,脑血管疾病是成人组(29.9%)和老年组(80.0%)患者最常见的癫痫病因,脑外伤(75.0%)是儿童继发性癫痫的主要原因。超过46.7%的患者使用一种抗癫痫药物进行治疗;无论使用单一抗癫痫药物治疗还是多种抗癫痫药物联合使用,丙戊酸都是最常使用的抗癫痫药物(单药治疗76.2%,联合使用91.8%)。结论徐州地区癫痫患者的病因随年龄的不同而有所差异,脑血管疾病是成年和老年患者最常见的病因。丙戊酸是徐州地区最常使用的抗癫痫药物。Objective To summarize the etiologic features and utilization patterns of antiepileptic drugs in people with epilepsy in Xuzhou.Methods Epilepsy patients who were treated in Xuzhou Central Hospital from December 2017 to December 2019 were selected.Their clinical data were collected through questionnaire and medical record analysis.Results A total of 199 patients were enrolled in the current study.Cerebrovascular disorders were the most common cause in the adult group(29.9%)and the elderly group(80.0%).Cerebral trauma(75.0%)was the major cause of children secondary epilepsy.More than 46.7%of patients received antiepileptic drug monotherapy.Valproic acid was the most frequently used antiepileptic drug(76.2%for monotherapy and 91.8%for multitherapy).Conclusions The etiologic features vary with the age of patients with epilepsy in Xuzhou.Cerebrovascular disorders are the most common cause of epilepsy among adults and elderly patients.Valproic acid is most widely used for the treatment of epilepsy in Xuzhou.

关 键 词：癫痫 病因 抗癫痫药物 丙戊酸 

分 类 号：R742.1[医药卫生—神经病学与精神病学]