参蛇偏瘫胶囊联合西医常规治疗中风后遗症的临床疗效及对其血液流变学指标的影响  

Clinical efficacy of Shenshe Piantan capsule combined with conventional western medicine in the treatment of ischemic stroke and its influence on hemorheology indexes

作　　者：焦永光 李燕梅[2] 李玲霞 李浩 JIAO Yong-guang;LI Yan-mei;LI Ling-xia(Department of Geriatrics,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou Henan 450000,China;Department of Encephalopathy,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou Henan 450000,China.)

机构地区：[1]河南省中医院老年病科,河南郑州450000 [2]河南中医药大学第一附属医院脑病科,河南郑州450000 [3]河北唐山开滦总院老年病科,河北唐山063001

出　　处：《临床和实验医学杂志》2022年第6期591-595,共5页Journal of Clinical and Experimental Medicine

基　　金：2019年度医学科学研究课题(编号:20191557)。

摘　　要：目的探讨参蛇偏瘫胶囊联合西医常规治疗对中风后遗症的临床疗效及对血液流变学指标的影响。方法前瞻性选取2019年2月至2020年2月就诊于河南中医药大学第一附属医院的中风后遗症患者80例,按照随机数字表法分为治疗组与对照组,各40例。治疗组给予参蛇偏瘫胶囊联合西医常规治疗,对照组给予西医常规治疗,疗程28 d。观察两组患者的临床疗效;分析两组患者治疗前、治疗28 d后的神经功能缺损评分[美国国立卫生研究院卒中量表(NIHSS)]、中医证候分级量化表、日常生活能力指数、血流变指标情况。结果治疗组治疗有效率为88.89%,高于对照组(61.76%),差异有统计学意义(P<0.05)。治疗前,两组患者的神经功能缺损评分、中医证候分级量化表、日常生活能力指数、血流变指标等比较,差异均无统计学意义(P>0.05);治疗28 d后,两组患者NIHSS评分、中医症候积分、高、低切全血还原黏度均较治疗前下降,且治疗组均低于对照组,差异均有统计学意义(P<0.05);治疗后,两组患者Barthel评分均较治疗前升高,且治疗组高于对照组,差异均有统计学意义(P<0.05)。结论参蛇偏瘫胶囊联合联合西医常规治疗中风后遗症疗效显著,可有效改善患者的NIHSS和中医症候积分,能有效改善机体血液流变学指标,有利于提高患者日常活动能力和改善生活质量。Objective To investigate the observation of the curative effect of Shenshe Pianban capsule combined with conventional western medicine treatment on the sequelae of ischemic stroke and its effect on hemorheology.Methods A total of 80 patients with ischemic stroke who were treated in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from February 2019 to February 2020 were prospectively selected.They were randomly divided into treatment group and control group with 40 cases each.The treatment group was given Shenshe Piantan capsules combined with conventional Western medicine treatment;the control group was given Western medicine conventional treatment for 28 days.The clinical efficacy of the two groups of patients was observed;the neurological deficit scores[NIH Stroke Scale(NIHSS)],TCM syndrome grading and quantitative scale,daily living ability index,and hemorheology indexes were analyzed before and 28 days after treatment.Results The total effective rate of the treatment group was 88.89%,which was higher than of the control group(61.76%),and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in neurological deficit score,TCM syndrome grading and quantitative scale,daily living ability index,and blood flow index between the two groups(P>0.05);after 28 days of treatment,the NIHSS score,TCM symptom score,high and low shear whole blood reduced viscosity of the two groups were decreased compared with those before treatment,and the above indexes in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the Barthel scores of the two groups were higher than those before treatment,and the treatment group was higher than in the control group,and the differences were statistically significant(P<0.05).Conclusion Shenshe Piantan capsule combined with conventional western medicine has a significant curative effect on the treatment of ischemic stroke,can ef

关 键 词：中风后遗症 参蛇偏瘫胶囊 血液流变学 疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]