二氧化碳激光联合重组人干扰素α-1b对脂溢性角化病治疗效果的影响  

The effect of carbon dioxide laser combined with recombinant human interferon α-1b on the treatment of seborrheic keratosis

作　　者：蔺辉 王晓馨[1] 宋颖[1] LIN Hui;WANG Xiao-xin;SONG Ying(Department of Dermatology,Baoji People's Hospital,Baoji Shaanxi 721000,China)

机构地区：[1]宝鸡市人民医院皮肤科,陕西宝鸡721000

出　　处：《临床和实验医学杂志》2022年第5期556-559,共4页Journal of Clinical and Experimental Medicine

基　　金：陕西省自然科学基础研究计划项目(编号:2019JQ-872)。

摘　　要：目的探讨二氧化碳激光联合重组人干扰素α-1b对脂溢性角化病治疗效果的影响。方法前瞻性选择2018年3月到2021年9月在宝鸡市人民医院诊治的脂溢性角化病患者98例为研究对象,根据随机数字表法分为联合组与对照组,各49例。对照组给予重组人干扰素α-1b治疗,10~20μg/次,隔日1次,联合组在此基础上给予二氧化碳激光治疗,1次/月,两组治疗观察8周,记录治疗效果。观察两组在治疗期间的不良反应。测定治疗前后表皮水分丢失、角质层含水量以及血清干扰素-γ(IFN-γ)含量。结果治疗后联合组的总有效率为97.96%,显著高于对照组的81.63%,差异有统计学意义(P<0.05)。两组在治疗期间的不良反应对比差异无统计学意义(P>0.05)。两组治疗后的水分丢失较治疗前降低,含水量较治疗前增加,且联合组的水分丢失为(18.11±3.29)%,低于对照组[(23.02±4.66)%],含水量为(29.78±3.88)%,高于对照组[(25.02±4.65)%],差异均有统计学意义(P<0.05)。两组治疗后的血清IFN-γ水平显著高于治疗前,联合组血清IFN-γ水平为(5.45±0.28)pg/mL,显著高于对照组[(2.14±0.14)pg/mL],差异均有统计学意义(P<0.05)。结论二氧化碳激光联合重组人干扰素α-1b对脂溢性角化病具有显著治疗效果,其可促进患者血清IFN-γ的分泌并改善皮肤状态,且安全性较好。Objective To investigate the effect of carbon dioxide laser combined with recombinant human interferonα-1b on the treatment of seborrheic keratosis.Methods A prospective selection of 98 patients with seborrheic keratosis who were diagnosed and treated in Baoji City People's Hospital from March 2018 to September 2021 were selected as the research objects.According to the random number table method,they were divided into a combination group and a control group,with 49 cases in each group.The control group was treated with recombinant human interferonα-1b,10-20μg/time,once every other day,and the combination group was given carbon dioxide laser treatment on this basis,1 time/month,both groups were treated and observed for 8 weeks,and the treatment effect was recorded.Adverse reactions were observed in both groups during the treatment period.Epidermal water loss,stratum corneum water content,and serum IFN-γlevels were measured before and after treatment.Results After treatment,the total effective rate of the combined group was 97.96%,which was significantly higher than 81.63%of the control group,the difference was statistically significant(P<0.05).The adverse reactions of the two groups during the treatment period were not statistically significant(P>0.05).The water loss after treatment in the two groups was lower than that before treatment,and the water content was increased compared with that before treatment,the water loss of the combined group was(18.11±3.29)%,which was lower than that of the control group[(23.02±4.66)%],and the water content was(29.78±3.88)%,which was higher than that of the control group[(25.02±4.65)]%,the differences were statistically significant(P<0.05).The levels of serum IFN-γin the two groups after treatment were significantly higher than those before treatment,and the level of serum IFN-γin the combined group was(5.45±0.28)pg/mL,which was significantly higher than that in the control group[(2.14±0.14)pg/mL],the difference was statistically significant(P<0.05).Conclusion Carbo

关 键 词：脂溢性角化病 二氧化碳激光 重组人干扰素Α-1B 干扰素Γ 

分 类 号：R739.5[医药卫生—肿瘤]