40~120μm直径三丙烯微球m-肝动脉化疗栓塞术治疗乏血供肝癌的疗效与安全性分析  

Efficacy and safety analysis of 40-120μm diameter tripropylene microspheres m-transcatheter arterial chemoembolization in the treatment of hypovascular hepatocellular carcinoma

作　　者：余海滨[1] 张克勤[1] 冷向北 王文英 万萍 欧阳兵[1] 杨文娟 YU Haibin;ZHANG Keqin;LENG Xiangbei;WANG Wenying;WAN Ping;OUYANG Bing;YANG Wenjuan(Department of Liver Oncology,Nanchang Ninth Hospital,Nanchang,Jiangxi,330002,China;Department of Infectious Diseases,Shanggao County People's Hospital,Yichun,Jiangxi,336400,China)

机构地区：[1]南昌市第九医院肝脏肿瘤科,江西南昌330002 [2]上高县人民医院感染科,江西宜春336400

出　　处：《当代医学》2022年第13期49-52,共4页Contemporary Medicine

基　　金：江西省卫生健康委科技计划课题(20204116)。

摘　　要：目的分析40~120μm直径三丙烯微球m-肝动脉化疗栓塞术(TACE)治疗乏血供肝癌的疗效及安全性。方法选取2017年8月至2019年8月南昌市第九医院收治的60例乏血供肝癌患者作为研究对象,按随机数字表法分为两组,各30例。两组均采用TACE治疗,观察组采用三丙烯微球作为栓塞剂,对照组采用碘化油作为栓塞剂,比较两组临床疗效、肿瘤标志物、不良反应发生率及生存率。结果观察组疾病控制率(93.33%)高于对照组(73.33%),差异有统计学意义(P<0.05)。治疗后,观察组甲胎蛋白(AFP)、甲胎蛋白异质体(AFP-L3)水平分别为(341.55±62.03)、(273.25±53.59)μg/L,均低于对照组的(619.42±75.98)、(321.29±78.30)μg/L,差异有统计学意义(P<0.05)。观察组生存率(90.00%)高于对照组(66.67%),差异有统计学意义(P<0.05)。两组发热、肝功能损伤、腹痛、血小板减少、恶心/呕吐、白细胞减少发生率比较差异均无统计学意义。结论采用三丙烯微球m-TACE治疗乏血供肝癌患者能提高疾病控制率,降低AFP及AFP-L3水平,延长生存期,安全可靠。Objective To analyze the efficacy and safety of 40-120μm diameter tripropylene microspheres m-transcatheter arterial chemoembolization(TACE)in the treatment of hypovascular hepatocellular carcinoma.Methods A total of 60 patients with hepatocellular carcinoma with hypovascularity who were admitted to Nanchang Ninth Hospital from August 2017 to August 2019 were selected as the research subjects,and they were divided into two groups according to the random number table method,with 30 cases in each group.Both groups were treated with TACE,the observation group was treated with tripropylene microspheres as the embolic agent,and the control group was treated with iodized oil as the embolic agent,the clinical efficacy,tumor markers,adverse reactions and survival rate were compared between the two groups.Results The disease control rate of the observation group(93.33%)was higher than that of the control group(73.33%),and the difference was statistically significant(P<0.05).After treatment,the levels of alpha-fetoprotein(AFP)and alpha-fetoprotein isoform(AFP-L3)in the observation group were(341.55±62.03)and(273.25±53.59)μg/L,respectively,which were lower than([619.42±75.98],[321.29±78.30]μg/L)in the control group,and the difference was statistically significant(P<0.05).The survival rate of the observation group(90.00%)was higher than that of the control group(66.67%),and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of fever,liver function damage,abdominal pain,thrombocytopenia,nausea/vomiting,and leukopenia between the two groups.Conclusion Tripropylene microspheres m-TACE therapy can improve the disease control rate,reduce the levels of AFP and AFP-L3,prolong the survival period of patients with hypovascular liver cancer,and is safe and reliable.

关 键 词：乏血供肝癌 三丙烯微球 肝动脉化疗栓塞术 肿瘤标志物 生存率 

分 类 号：R735.7[医药卫生—肿瘤]