脂肪酸结合蛋白在缺血性肠病患者中的相关性研究  

Reaserch on the Correlation of Fatty Acid Binding Protein in Patients with Ischemic Bowel Disease

作　　者：张伟伟[1] 王家旭 黄炎东 唐少波[1] 

机构地区：[1]南宁市第一人民医院,广西南宁530022

出　　处：《大众科技》2022年第3期94-97,44,共5页Popular Science & Technology

摘　　要：目的:通过检测缺血性肠病(ICBD)患者肠脂肪酸结合蛋白(I-FABP)表达水平,为ICBD患者的早期诊断、治疗监测以及预后评估提供客观指标。方法:连续选取南宁市第一人民医院2015年3月至2020年6月急性腹痛的患者72例,其中行肠系膜CTA及肠镜确诊ICBD的患者21例为观察组。另外51例为对照组,对各组患者年龄、性别、白细胞计数(WBC)、C-反应蛋白、D-二聚体以及I-FABP表达水平进行比较,运用受试者工作特征曲线(ROC),分析I-FABP预测其诊断的价值。结果:观察组I-FABP、D-二聚体高于对照组,差异有统计学意义(P<0.05);各组患者年龄、性别、体温、WBC、C反应蛋白等其他指标比较,差异无统计学意义(P>0.05)。I-FABP以131.5 ug/L为截断值,I-FABP评估患者患缺血性肠病风险的曲线下面积分别为0.850(95%CI0.762~0.938,P<0.05)。结论:早期检测患者血清I-FABP有助于ICBD的早期诊断。Objective: To detect the expression level of intestinal fatty acid binding protein(I-FABP) in patients with ischemic bowel disease(ICBD), so as to provide objective indicators for early diagnosis, treatment monitoring and prognosis evaluation of patients with ICBD. Methods: 72 patients with acute abdominal pain in The First People’s Hospital of Nangning from March 2015 to June 2020 were selected continuously, including 21 patients with icbd diagnosed by mesenteric CTA and colonoscopy as the observation group. The other 51 cases were the control group. The age, sex, white blood cell count(WBC), C-reactive protein, D-dimer and the expression level of I-FABP in each group were compared. The diagnostic value of I-FABP was analyzed by using the receiver operating characteristic curve(ROC). Results: The levels of I-FABP and D-dimer in the observation group were significantly higher than those in the control group(P<0.05);there were no significant differences in age, sex, body temperature, WBC, C-reactive protein and other indexes among the groups(P>0.05). I-FABP was truncated at 131.5 ug/l, the areas under the curve of I-FABP in assessing the risk of ischemic bowel disease were 0.850(95%CI0.762~0.938,P<0.05). Conclusion: Early detection of serum I-FABP is helpful to the early diagnosis of ICBD.

关 键 词：缺血性肠病 肠脂肪酸结合蛋白 诊断价值 

分 类 号：R574[医药卫生—消化系统]