血清前列腺特异性抗原对下尿路症状/良性前列腺梗阻患者前列腺体积的预测作用  

Predictive Effect of Serum Prostate-specific Antigen on Prostate Volume in Patients with Lower Urinary Tract Symptoms/Benign Prostatic Obstruction

作　　者：王有法 WANG Youfa(Daye Hospital of Traditional Chinese Medicine,Hubei Province,Daye 435100,China)

机构地区：[1]湖北省大冶市中医医院,湖北大冶435100

出　　处：《中国医学创新》2022年第7期154-158,共5页Medical Innovation of China

摘　　要：目的:探讨血清前列腺特异性抗原(PSA)水平对下尿路症状/良性前列腺梗阻(LUTS/BPO)患者前列腺体积(PV)的预测作用。方法:纳入2018年1月-2020年12月大冶市中医医院收治的420例LUTS/BPO患者,检测血清总前列腺特异性抗原(tPSA)、游离前列腺特异性抗原(fPSA)水平及PV,采用Pearson相关系数分析血清t PSA、f PSA、年龄与PV间的相关性,采用ROC分析血清t PSA、f PSA对PV的预测价值。结果:血清t PSA、f PSA水平及PV均随年龄的增长而明显增高(P<0.05);血清t PSA、f PSA水平均随PV的增大而明显增高(P<0.05);血清t PSA、f PSA、年龄均与PV之间存在明显正相关(P<0.05);血清t PSA预测PV<30 mL、30~49 mL、50~69 mL及≥70 mL的AUC分别为0.238、0.620、0.736、0.765;血清f PSA预测PV<30 mL、30~49 mL、50~69 mL及≥70 mL的AUC分别为0.227、0.631、0.742、0.769。血清t PSA预测PV 30~49 mL、50~69 mL及≥70 mL的最佳临界值分别为1.28、1.57、1.95 ng/mL;血清f PSA预测PV 30~49 mL、50~69 mL及≥70 mL的最佳临界值分别为0.29、0.42、0.54 ng/mL。结论:血清t PSA、f PSA均与LUTS/BPO患者PV呈明显正相关性,能够有效预测LUTS/BPO患者PV。Objective: To discuss the predictive effect of serum prostate-specific antigen(PSA) on prostate volume(PV) in patients with lower urinary tract symptoms/benign prostatic obstruction(LUTS/BPO). Method: A total of 420 patients with LUTS/BPO were included in Daye Hospital of Traditional Chinese Medicine from January 2018to December 2020. The serum levels of total prostate specific antigen(tPSA), free prostate specific antigen(fPSA) and PV were detected. The Pearson correlation coefficient was used to analyze the correlation between serum tPSA, fPSA,age and PV. The ROC was used to analyze the predictive value of serum tPSA, fPSA for PV. Result: The serum levels of tPSA, fPSA and PV were increased significantly with the growth of age(P<0.05). The serum levels of tPSA, fPSA were increased significantly with the increase of PV(P<0.05). The serum tPSA, fPSA, age were significantly positively correlated with PV(P<0.05). Serum tPSA predicted that the AUC of PV<30 mL, 30-49 mL, 50-69 mL and ≥70 mL were 0.238, 0.620, 0.736 and 0.765, respectively. Serum fPSA predicted that the AUC of PV<30 mL, 30-49 mL, 50-69 mL and ≥70 mL were 0.227, 0.631, 0.742 and 0.769, respectively. The optimal critical values of serum tPSA for predicting PV 30-49 mL, 50-69 mL and ≥70 mL were 1.28, 1.57 and 1.95 ng/mL, respectively. The optimal critical values of serum fPSA for predicting PV 30~49 mL, 50~69 mL and ≥70 mL were 0.29, 0.42, 0.54 ng/mL, respectively.Conclusion: The serum tPSA and fPSA are significantly positively correlated with PV in patients with LUTS/BPO,which can effectively predict PV in patients with LUTS/BPO.

关 键 词：良性前列腺增生 下尿路症状/良性前列腺梗阻 前列腺特异性抗原 前列腺体积 预测作用 

分 类 号：R737.25[医药卫生—肿瘤]