HIF1A/VEGFA/KDR在软组织肉瘤中表达及其与患者预后的关系  

HIF1A/Expression of VEGFA/KDR in soft tissue sarcoma and its relationship with prognosis

作　　者：王玉丽[1] 郭志涛[2] WANG Yu-li;GUO Zhi-tao(Department of Clinical Laboratory,Tianjin Medical University General Hospital,Tianjin 300052,China;不详)

机构地区：[1]天津医科大学总医院医学检验科,天津300052 [2]天津市西青医院骨一科,天津300380

出　　处：《中国处方药》2022年第4期6-8,共3页Journal of China Prescription Drug

摘　　要：目的探讨HIF1A/VEGFA/KDR在软组织肉瘤中表达及其与患者预后的关系。方法从cBioPortal网站和Xenabrowser网站获得TCGA 265例软组织肉瘤样本相关基因突变和表达量数据,通过OncoPrinter软件进行基因突变互斥和共表达分析,Spearman非参数相关进行基因相关性分析,Xenabrowser获得基因相关性热图,Kaplan-Meier法和Log-Rank检验进行生存分析。结果软组织肉瘤中HIF1A/VEGFA/KDR的拷贝数变化和基因突变存在互斥趋势(P>0.01),HIF1A/VEGFA/KDR表达量存在正相关(P<0.01),HIF1A/VEGFA/KDR的拷贝数扩增的患者总生存期和无病生存期显著低于无扩增患者(P<0.05)。结论靶向HIF1A/VEGFA/KDR可作为软组织肉瘤的治疗手段之一。Objective To investigate HIF1A/Expression of VEGFA/KDR in soft tissue sarcoma and its relationship with prognosis.Methods Genome and gene expression data of 265 STS samples were gotten from cBioPortal and Xenabrowser website.The mutual exclusivity and co-occurrence were preformed using Oncoprinter.Spearman nonparametric correlation was used to assess the correlation between HIF1A/VEGFA/KDR.Gene expression heatmap was obtained from Xenabrowser,and survival analysis was carried out by Kaplan Meier method and Log-Rank test.Results There were tendencies towards mutual exclusivity between HIF1A/VEGFA/KDR mutation and copy number alterations(P>0.01),and there were positive correlation between the mRNA expression of HIF1A/VEGFA/KDR(P<0.01).The overall survival(OS)and disease free survival(DFS)time of STS patients with the three genes alterations is significantly worse than that of the patients without genes alterations(P<0.05).Conclusion Targeting HIF1A/VEGFA/KDR can be used as one of the treatment methods of soft tissue sarcoma.

关 键 词：血管生成 软组织肉瘤 HIF1A/VEGFA/KDR 基因组学 

分 类 号：R738.6[医药卫生—肿瘤]