高频重复经颅磁刺激治疗精神分裂症的临床研究  

Clinical study of high frequency repetitive transcranial magnetic stimulation in the treatment of schizophrenia

作　　者：郭伟坚[1] 李荷花[1] 黄园园[1] 朱志敏 吴逢春 GUO Wei-jian;LI He-hua;HUANG Yuan-yuan(The Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou 510370,China;不详)

机构地区：[1]广州医科大学附属脑科医院,广州510300 [2]广东省精神疾病转化医学工程技术研究中心,广州510300

出　　处：《中国处方药》2022年第4期14-16,共3页Journal of China Prescription Drug

基　　金：广东省中医药卫生科技项目(20211306)。

摘　　要：目的探究高频重复经颅磁刺激(rTMS)能否改善稳定期精神分裂症患者的认知功能。方法使用随机双盲对照方法将符合入组标准的患者随机分为真刺激组(35例)和伪刺激组(35例),经4周的高频重复经颅磁刺激治疗,治疗期间药物治疗不变;使用协方差分析和多元方差分析比较治疗前后两组间PANSS和RBANS减分值的差异。结果两组治疗前后PANSS和RBANS减分值比较差异无统计学意义(P>0.05)。结论rTMS治疗精神分裂症患者的认知功能和精神症状仍待进一步的探索。Objective To investigate whether repetitive transcranial magnetic stimulation(rTMS)can improve cognitive function in stable schizophrenia.Methods A randomized double-blind control method was used to randomly divide patients who met the enrollment criteria into a true stimulation group(n=35)and a pseudo-stimulation group(n=35),and they were treated with high-frequency repeated transcranial magnetic stimulation for 4 weeks.The medication remains unchanged during the treatment period.Covariance analysis and multivariate analysis of variance were used to compare the differences on PANSS and RBANS scores between the two groups before and after treatment.Results There was no significant difference in the scores of PANSS and RBANS between the two groups before and after treatment(P>0.05).Conclusion The cognitive function and mental symptoms of schizophrenia patients treated with rTMS need to be further explored.

关 键 词：精神分裂症 RTMS 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]