血清卵泡抑素对甲状腺癌的诊断及预后影响  

The influence of serum follistatin on the diagnosis and prognosis of thyroid cancer

作　　者：叶艾竹[1] 牛志杰 井沆[1] YE Ai-zhu;NIU Zhi-jie;JING Hang(Clinical laboratory,GuizhouProvincial People's Hospital,Guizhou 550000,China)

机构地区：[1]贵州省人民医院检验科,贵阳550000

出　　处：《中国处方药》2022年第4期159-161,共3页Journal of China Prescription Drug

摘　　要：目的探讨血清卵泡抑素(FS)对甲状腺癌的诊断与预测预后的价值。方法选择2018年4月~2020年4月收治的86例甲状腺癌患者,选择同期90例甲状腺良性病变患者和50例健康体检者为研究对象,检测血清FS水平、甲状腺球蛋白(Tg)和降钙素,采用受试者工作特征曲线(ROC)分析血清FS、Tg、降钙素对甲状腺癌的诊断效能,并分析血清FS、Tg、降钙素与甲状腺癌预后指数的相关性。结果三组间血清Tg、降钙素、FS水平差异具有统计学意义(P<0.05),其中甲状腺癌组的血清Tg、降钙素、FS水平均明显高于甲状腺良性病变组和健康对照组,差异比较有统计学意义(P<0.05);血清FS以483.10 ng/L为截断值,AUC为0.842,灵敏度、特异度、准确度分别为45.3%、51.4%、51.8%,低于血清Tg、降钙素;86例甲状腺癌患者的预后指数为61.57(43.20~84.93),相关性分析显示,血清Tg、FS水平与预后指数无关(r=0.218、0.084,P>0.05),而血清降钙素水平与预后指数呈负相关(r=-0.604,P<0.05)。结论血清FS在甲状腺癌诊断及预测预后方面的价值有限。Objective To explore the value of serum follistatin(FS)in the diagnosis and prognosis of thyroid cancer.Methods From April 2018 to April 2020,86 patients with thyroid cancer,90 patients with benign thyroid disease and 50 healthy subjects were selected as the research subjects.Serum FS,globulin(Tg)and calcitonin levelswere detected.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic efficacy of serum FS,TG and calcitonin in thyroid cancer,and analyze the correlation between serum FS,Tg,and calcitonin and the prognostic index of thyroid cancer.Results The differences in serum Tg,calcitonin and FS levels between the three groups were statistically significant(P<0.05).The serum Tg,calcitonin and FS levels in the thyroid cancer group were significantly higher than those in the benign thyroid disease group and healthy controls group,the comparison was statistically significant(P<0.05);The cut-off value of serum FS was 483.10 ng/L,and the AUC was 0.842,and the sensitivity,specificity and accuracy were 45.3%,51.4%and 51.8%,respectively,which were lower than those of serum Tg and calcitonin;the prognostic index of 86 patients with thyroid cancer was 61.57(43.20~84.93).Correlation analysis showed that serum Tg and FS levels have nothing to do with the prognostic index(r=0.218,0.084,P>0.05),while the serum calcitonin level is negatively correlated with the prognostic index(r=-0.604,P<0.05).Conclusion The value of serum FS in the diagnosis and prognosis of thyroid cancer is limited.

关 键 词：甲状腺癌 卵泡抑素 诊断 预后 

分 类 号：R736.1[医药卫生—肿瘤]