不同干细胞来源的外泌体在缺血性心脏病中的促血管新生作用  

Application of Exosomes Derived from Various Stem Cells in Ischemic Heart Disease

作　　者：肖轶[1] 余国龙[1] XIAO Yi;YU Guolong(Xiangya Hospital of Central South University,Changsha 410008,Hunan,China)

机构地区：[1]中南大学湘雅医院,湖南长沙410008

出　　处：《心血管病学进展》2022年第4期293-296,共4页Advances in Cardiovascular Diseases

基　　金：湖南省自然科学基金(2020JJ4921)。

摘　　要：缺血性心脏病是指各种原因造成心肌供血量不足,导致氧气和营养物质供应不足,引起各种心脏功能障碍。促血管新生是治疗缺血性心脏病的一个关键因素。越来越多的研究表明,干细胞来源的外泌体作为一种细胞间相互作用的媒介,为缺血性心脏病的治疗提供了新的可能。现对各种干细胞来源的外泌体在治疗缺血性心脏病中促血管新生作用及机制做一综述。Ischemic heart disease refers to the lack of myocardial blood supply caused by various factors,resulting in the lack of oxygen and nutrients supply and cardiac dysfunction.Promoting angiogenesis is a key factor in the treatment of ischemic heart disease.More and more studies have shown that stem cell-derived exosomes,as a messager of cellular interaction,provide a new strategy for the treatment of ischemic heart disease.This paper aims to review the therapeutic effect of exosomes from various stem cells in ischemic heart disease and its mechanism.

关 键 词：外泌体 缺血性心脏病 血管新生 干细胞 

分 类 号：R74[医药卫生—神经病学与精神病学]