儿童腹膜后结节型和混合型节细胞神经母细胞瘤的临床及CT表现  

CT findings and clinical features of retroperitoneal nodular and intermixed ganglioneuroblastoma in children

作　　者：王浩入 陈欣[1] 张黎[1] 丁浩 何玲[1] WANG Hao-ru;CHEN Xin;ZHANG Li;DING Hao;HE Ling(Department of Radiology,Children's Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院放射科国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室,重庆400014

出　　处：《中国临床医学影像杂志》2022年第4期279-282,共4页Journal of China Clinic Medical Imaging

基　　金：重庆市教育委员会科学技术研究项目(KJQN202000440);重庆市科卫联合医学科研项目(2020FYYX128);重庆市渝中区基础研究与前沿探索项目(20200155);重庆市技术预见与制度创新项目(cstc2021jsyj-yzysbAX0019)。

摘　　要：目的:比较儿童腹膜后结节型(GNBn)和混合型(GNBi)节细胞神经母细胞瘤(GNB)的临床及CT表现。方法:回顾性分析GNBn(n=25)和GNBi(n=27)患者的临床及CT影像资料。组间比较INRGSS分期、区域淋巴结及骨髓转移等。组间比较病灶分布、横断面最大径、形态、边界、钙化情况、超逾中线、强化方式、实质各期平均CT值、邻近结构关系等影像学表现。结果:GNBi多位于L1期,较少发生区域淋巴结及骨髓转移(P均<0.05)。组间病变分布、横断面最大径、钙化情况比较无统计学差异(P均>0.05),GNBn多表现为形态不规则、边界模糊、超逾中线(P均<0.05)。组间强化方式、静脉期实质平均CT值、邻近椎体骨质破坏比较无统计学差异(P均>0.05),GNBn平扫期与动脉期实质平均CT值较高,易包埋邻近血管(P均<0.05)。结论:腹膜后GNB不同病理亚型的临床和CT表现存在不同,对腹膜后GNB进行影像学研究时应考虑其病理亚型。Objective:To compare the CT findings and clinical features of retroperitoneal nodular(GNBn)and intermixed(GNBi)ganglioneuroblastoma(GNB)in children.Methods:CT findings and clinical features of GNBn(n=25)and GNBi(n=27)were retrospectively analyzed.Clinical features,such as INRGSS stages,regional lymph node and bone marrow metastasis,were compared between GNBn and GNBi.CT findings,such as location,maximum diameter,morphology,border,calcification,infiltration across midline,enhancement pattern,mean CT value of parenchyma at each stage and relationship with adjacent structures,were compared between GNBn and GNBi.Results:GNBi was mostly in L1 stage,with less regional lymph node and bone marrow metastasis compared to GNBn(all P<0.05).There were no significant differences in location,maximum diameter and calcification between two groups(all P>0.05).GNBn was prone to be irregular morphology,fuzzy boundary,and infiltrating across the midline(all P<0.05).There were no statistically significant difference in enhancement pattern,mean CT value of parenchyma in venous phase and bone destruction of adjacent vertebral body between two groups(all P>0.05).The mean parenchymal CT value of GNBn in plain and arterial phase was higher,and the adjacent vessels were mostly encased in GNBn(all P<0.05).Conclusion:The CT findings and clinical features of retroperitoneal GNBn and GNBi are somehow different,so the pathological subtypes should be considered when conducting radiological studies on retroperitoneal GNB.

关 键 词：腹膜后肿瘤 神经母细胞瘤 儿童 体层摄影术 X线计算机 

分 类 号：R735.4[医药卫生—肿瘤] R814.42[医药卫生—临床医学]