归脾汤加味联合阿立哌唑治疗心脾两虚证精神分裂症临床研究  

Clinical Study of Modified Guipi Tang Combined with Aripiprazole for Schizophrenia with Heart-Spleen Deficiency Syndrome

作　　者：陈晓燕 曹峰 何月敏 CHEN Xiaoyan;CAO Feng;HE Yuemin

机构地区：[1]绍兴市第七人民医院临床药学科,浙江绍兴312000 [2]绍兴市第七人民医院精神科,浙江绍兴312000 [3]绍兴市第七人民医院中医科,浙江绍兴312000

出　　处：《新中医》2022年第6期38-41,共4页New Chinese Medicine

摘　　要：目的:观察归脾汤加味联合阿立哌唑治疗心脾两虚证精神分裂症的临床疗效。方法:选取70例精神分裂症患者,按随机数字表法分为对照组和观察组各35例。对照组仅口服阿立哌唑片治疗,观察组在对照组的基础上给予归脾汤加味治疗。2组均连续治疗12周。观察比较2组临床疗效、精神分裂症相关阳性与阴性症状量表(PANSS)、精神分裂症社会功能住院精神社会功能评定量表(SSPI)、自我感受负担量表(SPBS)评分。结果:观察组总有效率为82.86%,对照组为57.14%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组PANSS评分均较治疗前明显减少(P<0.01),SSPI评分均较治疗前明显增加(P<0.01),且观察组治疗后PANSS、SSPI评分改善较对照组更显著(P<0.01)。治疗后,2组SPBS量表中身体因素、情感因素、经济因素评分均较治疗前显著降低(P<0.01);且观察组上述各项评分均明显低于对照组(P<0.01)。结论:归脾汤加味治疗心脾两虚证精神分裂症的疗效显著,可有效改善患者的临床症状、社会功能,有效减轻自我感受负担。Objective:To observe the clinical effect of modified Guipi tang combined with aripiprazole for schizophrenia with heart-spleen deficiency syndrome. Methods: A total of 70 cases of patients with schizophrenia were selected and divided into the control group and the observation group according to the random number table method,with 35 cases in each group. The control group was given the oral administration of aripiprazole tablets, and the observation group was additionally treated with modified Guipi tang based on the treatment of the control group. Both groups were continuously treated for 12 weeks. Clinical effects as well as scores of schizophrenia-related syndromes in Positive and Negative Syndrome Scale(PANSS),the Scale of Social Function in Psychosis Inpatients(SSPI),and the Self-Perceived Burden Scale(SPBS) were observed and compared between the two groups. Results: The total effective rate was 82.86% in the observation group and 57.14% in the observation group, the difference being significant(P<0.05). After treatment, the scores of PANSS in the two groups were significantly decreased when compared with those before treatment(P<0.01),and the SSPI scores were significantly increased(P<0.01);the improvement of PANSS and SSPI scores in the observation group was more significant than that in the control group(P<0.01). After treatment,scores of physical,emotional,and financial support in SPBS in the two groups were significantly decreased when compared with those before treatment(P<0.01),and the above three scores in the observation were significantly lower than those in the control group(P<0.01). Conclusion:modified Guipi tang has a significantly curative effect in the treatment of schizophrenia with heart-spleen deficiency syndrome,and it can effectively improve clinical symptoms and social function,and reduce self-perceived burden.

关 键 词：精神分裂症 心脾两虚证 归脾汤 阿立哌唑 自我感受负担量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]