恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化对患者肝功能及血清HA、Ⅳ-C、PC-Ⅲ水平的影响  

Effect of Entecavir Combined with Compound Glycyrrhizin on Liver Function and Serum Levels of HA,Ⅳ-C and PC-Ⅲin Patients with Hepatitis B Cirrhosis

作　　者：姜海燕[1] JIANG Hai-yan(Department of Infection,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]佳木斯市中心医院感染科,黑龙江佳木斯154002

出　　处：《医学信息》2022年第9期144-146,共3页Journal of Medical Information

摘　　要：目的观察恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化临床疗效及其对患者肝功能及血清HA、Ⅳ-C、PC-Ⅲ水平的影响。方法选取2020年5月-2021年1月我院诊治的78例乙型肝炎肝硬化患者为研究对象,采用随机数字表法分为对照组和观察组,各39例。对照组采用恩替卡韦治疗,观察组在对照组基础上联合复方甘草酸苷治疗,比较两组临床疗效、肝功能指标[总胆红素(TBIL)、天门冬氨酸酶(AST)、丙氨酸转氨酶(ALT)]、肝纤维化指标[血清透明质酸(HA)、IV型胶原(Ⅳ-C)、Ⅲ型前胶原(PC-Ⅲ)]以及不良反应发生情况。结果观察组治疗总有效率为94.87%,高于对照组的82.05%(P<0.05);两组TBIL、AST、ALT均低于治疗前,且观察组低于对照组(P<0.05);两组HA、Ⅳ-C、PC-Ⅲ水平均低于治疗前,且观察组低于对照组(P<0.05);观察组不良反应发生率为5.13%,低于对照组的7.69%,但差异无统计学意义(P>0.05)。结论恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化效果较好,可提高治疗总有效率,改善肝功能,降低肝纤维化指标,且不良反应少,是一种安全有效的治疗方案。Objective To observe the clinical efficacy of entecavir combined with compound glycyrrhizin in the treatment of hepatitis B cirrhosis and its influence on liver function and serum levels of HA,Ⅳ-C and PC-Ⅲ.Methods A total of 78 patients with hepatitis B cirrhosis who were treated in our hospital from May 2020 to January 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 39 cases in each group.The control group was treated with entecavir,and the observation group was treated with compound glycyrrhizin on the basis of the control group.The clinical efficacy,liver function indexes[total bilirubin(TBIL),aspartate aminotransferase(AST),alanine aminotransferase(ALT)],liver fibrosis indexes[serum hyaluronic acid(HA),typeⅣcollagen(Ⅳ-C),typeⅢprocollagen(PC-Ⅲ)]and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.87%,which was higher than 82.05%of the control group(P<0.05).The levels of TBIL,AST and ALT in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).The levels of HA,Ⅳ-C and PC-Ⅲin the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).The incidence of adverse reactions in the observation group was 5.12%,which was lower than 7.69%in the control group,but the difference was not statistically significant(P>0.05).Conclusion Entecavir combined with compound glycyrrhizin is effective in the treatment of hepatitis B cirrhosis,which can improve the total effective rate,improve liver function,reduce liver fibrosis index,and has less adverse reactions.It is a safe and effective treatment plan.

关 键 词：恩替卡韦 复方甘草酸苷 乙型肝炎肝硬化 肝功能 

分 类 号：R575.2[医药卫生—消化系统]