终末期原发性胆汁性肝硬化23例临床特点分析  

Clinical analysis of 23 cases of end-stage primary biliary cirrhosis

作　　者：张丽丽 胡建华 靳华 徐辉 ZHANG Li-li;HU Jian-hua;JIN Hua;XU Hui(Center for Integrated Traditional Chinese and Western Medicine,Beijing You’an Hospital Affiliated to Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院中西医结合中心,北京100069

出　　处：《肝脏》2022年第3期337-340,共4页Chinese Hepatology

摘　　要：目的总结终末期原发性胆汁性肝硬化患者的临床及实验室检查结果。方法回顾性总结分析2018年1月至2020年12月首都医科大学附属北京佑安医院确诊的23例终末期原发性胆汁性肝硬化患者的实验室检查结果。结果23例终末期原发性胆汁性肝硬化患者中,黄疸的出现率为100%,脾大、脾厚共有18例(78.26%);贫血以轻中度贫血为主,血红蛋白在90~120 g/L范围内的占43.39%,在60~90 g/L范围内的占47.83%;ALP升高者占47.82%,γ-GT升高者占8.70%,ALT(56.13±119.05)U/L,AST(92.04±124.46)U/L为轻中度升高,且指标升降程度与疾病严重程度无明显的相关性;总胆固醇(2.07±0.57)mmol/L、甘油三酯(0.99±0.54)mmol/L,血脂紊乱表现程度与早期PBC患者明显不同。结论终末期PBC患者的部分化验指标与常见PBC患者的指标有所不同,病情更为严重,预后更差。Objective To summarize the clinical and laboratory findings of patients with end-stage primary biliary cirrhosis(PBC).Methods A retrospective summary and analysis of the laboratory examination results of 23 patients with end-stage PBC diagnosed in Beijing You’an Hospital affiliated to Capital Medical University,from January 2018 to December 2020.Results Among the 23 patients with end-stage PBC,the incidence of jaundice was 100%,and there were 18 cases(78.26%)with splenomegaly and thick spleen.The anemia was mainly mild to moderate anemia,and the hemoglobin of patients was 90-120 g/L,accounted for 43.39%,patients with hemoglobin of 60-90 g/L accounted for 47.83%.Patients with increased ALP accounted for 47.82%,and with increasedγ-GT accounted for 8.70%.ALT(56.13±119.05)U/L,AST(92.04±124.46)U/L were considered to be a mild to moderate increase,and the degree of index rise and fall had no obvious correlation with the severity of the disease.Total cholesterol was(2.07±0.57)mmol/L,triglyceride was(0.99±0.54)mmol/L,and the degree of dyslipidemia of patients with end-stage PBC was significantly different from patients with early PBC.Conclusion Part of the laboratory indicators of patients with end-stage PBC are different from those of common PBC patients,the condition is more serious and the prognosis is worse.

关 键 词：终末期肝病 原发性胆汁性肝硬化 临床分析 

分 类 号：R57[医药卫生—消化系统]