CD4^(+)T细胞平衡失调与宫颈癌发生、进展及预后的关系研究  

Correlation of CD4^(+)T lymphocytes dysequilibrium with occurrence,progression and prognosis of cervical cancer

作　　者：毛爱荣 李战飞 韩玉新 袁晓雁 陈静 MAO Airong;LI Zhanfei;HAN Yuxin;YUAN Xiaoyan;CHEN Jing(First Department of Gynaecology,Jiaozuo District,No.988 Hospital of Joint Logistics Support Force,Jiaozuo 454150,He’nan,China;Department of Obstetrics and Gynecology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong,China)

机构地区：[1]解放军联勤保障部队第988医院焦作院区妇科一区,河南焦作454150 [2]南方医科大学南方医院妇产科,广州5105150

出　　处：《癌症进展》2022年第6期616-618,623,共4页Oncology Progress

摘　　要：目的探讨宫颈癌患者肿瘤组织中CD4^(+)T淋巴细胞平衡失调与宫颈癌发生、进展及预后之间的关系。方法收集48例宫颈癌患者的临床资料,设为观察组,选取同期健康体检的52例女性,设为对照组。对观察组患者进行随访,了解患者生存情况。对比γ干扰素(IFN-γ)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)在两组中的表达情况,采用Logistic回归模型分析宫颈癌患者预后的影响因素。结果观察组患者IFN-γ、IL-2、IL-4、IL-6阳性表达率均高于对照组,差异均有统计学意义(P﹤0.05)。IFN-γ、IL-2、IL-4、IL-6阳性表达患者平均生存期分别短于IFN-γ、IL-2、IL-4、IL-6阴性表达患者(P﹤0.05)。经非条件多因素Logistic回归模型进一步分析得出,国际妇产科联盟(FIGO)分期为Ⅲ~Ⅳ期、分化程度为中~低分化、有淋巴结转移、IFN-γ阳性、IL-2阳性、IL-4阳性、IL-6阳性均为宫颈癌患者预后的独立危险因素(P﹤0.05)。结论FIGO分期为Ⅲ~Ⅳ期、分化程度为中~低分化、有淋巴结转移、IFN-γ阳性、IL-2阳性、IL-4阳性、IL-6阳性表达宫颈癌患者预后相对较差。Objective To explore the correlation of CD4^(+) T lymphocytes dysequilibrium in tumor tissues with the occurrence, progression and prognosis of cervical cancer. Method The clinical data of 48 patients with cervical cancer were collected as the observation group. During the same period, 52 women who underwent physical examination were selected as the control group. The observation group was followed up to evaluate the survival of the patients. The expressions of interferon-γ(IFN-γ), interleukin-2(IL-2), interleukin-4(IL-4), and interleukin-6(IL-6) between the two groups were compared, and the Logistic regression was used to analyze the factors affecting the prognosis of patients. Result The positive expression rates of IFN-γ, IL-2, IL-4, and IL-6 in the observation group were higher than those in the control group(P<0.05);mean survival time of patients with positive expressions of IFN-γ, IL-2, IL-4, and IL-6 were significantly shorter than that with negative expression(P<0.05);unconditional multivariate Logistic regression model showed that the International Federation of Gynecology and Obstetrics(FIGO) stage Ⅲ-Ⅳ, medium-poor differentiation, lymph node metastasis, and positive expression of IFN-γ, IL-2, IL-4, IL-6 were independent risk factors affecting the prognosis of patients with cervical cancer(P<0.05). Conclusion The prognosis is poor for cervical cancer patients with FIGO stage Ⅲ-Ⅳ, medium-poor differentiation, lymph node metastasis, and positive expression of IFN-γ, IL-2, IL-4, IL-6.

关 键 词：CD4^(+)T细胞 平衡失调 宫颈癌 预后 

分 类 号：R737.33[医药卫生—肿瘤]