VDR基因多态性与恶性肿瘤相关性研究进展  

Research Progress on Correlation between VDR Gene Polymorphism and Malignant Cancer

作　　者：李云鹏 肖民辉[2] 肖龙[2] 徐万超[2] LI Yunpeng;XIAO Minhui;XIAO Long;XU Wanchao(The Fourth People’s Hospital of Yunnan Province,Dali 671000,China;不详)

机构地区：[1]云南省第四人民医院,大理大学第一附属医院,云南大理671000 [2]云南省第一人民医院,昆明理工大学附属医院

出　　处：《中外医学研究》2022年第10期175-178,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：维生素D(VD)的水平对癌症的发生和发展有重大影响,VD通过其受体(VDR)的作用调节炎症、免疫反应和抑癌,VDR是一种细胞内激素受体,存在于许多细胞途径中,特异性结合1,25-二羟基维生素D;[1,25(OH);D;],并与靶基因的特定核苷酸序列相互作用,产生多种生物效应。VDR表现出多种基因多态性,并与多种肿瘤存在相关性。本文综述了VDR基因多态性与恶性肿瘤相关性研究进展,以期为医学工作者提供参考和借鉴。The level of vitamin D(VD)has a significant impact on the occurrence and development of cancer.VD regulates inflammation,immune response and cancer suppression through the function of its receptor(VDR).VDR is an intracellular hormone receptor,which exists in many cellular pathways,specifically binds to 1,25-dihydroxy vitamin D;[1,25(OH);D;],and interacts with the specific nucleotide sequence of the target gene,and produces a variety of biological effects.VDR shows a variety of gene polymorphisms and is associated with a variety of tumors.This paper reviews the research progress on the correlation between VDR gene polymorphism and malignant tumor,in order to provide reference and borrowing for medical workers.

关 键 词：维生素D 维生素D受体 基因多态性 恶性肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]