缺血性脑卒中血脑屏障受损及修复的神经炎性机制研究进展  

Research progress on neuroinflammatory mechanisms of blood-brain barrier damage and repair in ischemic stroke

作　　者：杜仁峰 余波 潘丹红 蔺雁萍 王清华 李永男[3] 侯双兴 DU Renfeng;YU Bo;PAN Danhong;LIN Yanping;WANG Qinghua;LI Yongnan;HOU Shuangxing(Department of Neurology,Shanghai Pudong Hospital-Fudan University Pudong Medical Center,Shanghai 201399,P.R.China;Department of Vascular Surgery,Shanghai Pudong Hospital-Fudan University Pudong Medical Center,Shanghai 201399,P.R.China;Department of Neurology,the Fourth Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001,P.R.China)

机构地区：[1]上海市浦东医院,复旦大学附属浦东医院神经内科,上海201399 [2]上海市浦东医院,复旦大学附属浦东医院血管外科,上海201399 [3]哈尔滨医科大学附属第四医院神经内科,哈尔滨150001

出　　处：《华西医学》2022年第4期622-626,共5页West China Medical Journal

基　　金：上海市浦东新区卫生系统重点学科群建设资助(PWZxq2017-09);上海市浦东医院重点学科项目(Zdxk2020-09)。

摘　　要：缺血性脑卒中(ischemic stroke,IS)是目前威胁人类健康的重要疾病之一,IS的发生发展过程可触发一系列复杂的病理生理改变,包括血脑屏障受损、离子失衡、氧化应激、线粒体损伤等,最终导致缺血区神经细胞的凋亡及坏死。其中,血脑屏障受损是IS患者出现脑水肿、出血转化及预后不良的关键因素,而神经炎性反应在血脑屏障受损及修复过程中发挥重要作用。该文主要围绕胶质细胞、促炎性细胞因子及基质金属蛋白酶介导的神经炎性反应与IS血脑屏障受损及修复的相关机制进行综述,以期为IS的治疗提供新方向。Ischemic stroke(IS) is one of the important diseases threatening human health. The occurrence and development of IS can trigger a series of complex pathophysiological changes, including damage to the blood-brain barrier, ion imbalance, oxidative stress, mitochondrial damage, which ultimately lead to the apoptosis and necrosis of nerve cells in the ischemic area. Impaired blood-brain barrier is a key factor for cerebral edema, hemorrhagic transformation and poor prognosis in patients with IS, and neuroinflammatory response plays an important role in the damage and repair of the blood-brain barrier. This article mainly focuses on the neuroinflammatory response mediated by glial cells, pro-inflammatory cytokines and matrix metalloproteinases and the related mechanisms of IS blood-brain barrier damage and repair, in order to provide new directions for the treatment of IS.

关 键 词：缺血性脑卒中 血脑屏障 神经炎性 胶质细胞 

分 类 号：R743.3[医药卫生—神经病学与精神病学]