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作 者:Shuang Chen Yongchu Huang Yuchun Cao Yong Zhang
出 处:《Oncology and Translational Medicine》2022年第2期104-108,共5页肿瘤学与转化医学(英文版)
基 金:Supported by a grant from the National Natural Sciences Foundation of China(No.81974308).
摘 要:We present a rare case of nasal-type CD56-negative NK/T-cell lymphoma.The patient developed hemophagocytic syndrome during diagnosis and treatment.The patient presented to our hospital(Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China)with“nasal congestion for 3 months and scattered erythema,nodules,and ulcers all over the body for 1 month.”We analyzed clinical manifestations,skin histopathology,immunohistochemistry,and in situ hybridization results.Histopathology of the skin revealed a moderate amount of atypical lymphocyte infiltration between the entire dermis and collagen bundles.Immunohistochemistry showed the following:CD30(+),TIA-1(+),CD3(2GV6)(+),CD5 part(+),CD8 part(+),CD43(+),CD56(-),CD4(-),CD20(-),PAX5(-),PCK(-),P63(-),P40(-),EGFR(-),Ki-67(the hot spot LI is approximately 80%),and in situ hybridization EBER-ROCH(+).The diagnosis made was“NK/T cell lymphoma nasal type”.This type of lymphoma is aggressive,progresses quickly,and has a poor prognosis.Early clinical manifestations are extremely atypical,especially in the absence of rash.Analysis of the skin manifestations of the disease has a positive effect on its early diagnosis,early treatment,and prognosis.
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