基于红外眼动系统探讨帕金森病多模式视觉探索障碍的发生机制  

Mechanism of multimodel visual exploration disorder in Parkinson's disease based on an infrared eye movement system

作　　者：杨旭[1] 杨培红[2] Yang Xu;Yang Pei-Hong(Department of Neurology,Dalian Friendship Hospital,Dalian,Liaoning 116001,China;Department of Medical Imaging,Dalian Friendship Hospital,Dalian,Liaoning 116001,China)

机构地区：[1]大连市友谊医院神经内科,辽宁大连116001 [2]大连市友谊医院影像科,辽宁大连116001

出　　处：《解放军医学杂志》2022年第4期382-389,共8页Medical Journal of Chinese People's Liberation Army

摘　　要：目的通过红外眼动评估系统记录并分析目标探索任务中视觉信息处理系统眼动指标的疾病效应与衰老效应,探讨帕金森病患者视觉探索障碍的发生机制。方法本研究为横断面研究。纳入2020年10月-2021年6月于大连市友谊医院运动障碍门诊临床确诊且正在使用多巴胺能药物的认知正常的帕金森病患者32例作为帕金森病组,另将本院体检中心招募的年龄、性别及受教育程度相匹配且认知正常的健康志愿者33例作为与帕金森病组年龄匹配的正常对照组(AMC组),以及本院医护实习学生中招募的性别及受教育程度匹配的33例健康志愿者作为青年正常对照组(YC组)。所有受试者均进行代表视觉信息处理能力的图形匹配任务(时钟匹配任务与倒转时钟匹配任务)和代表动眼肌功能的扫视类任务,同时使用红外眼动评估系统记录各组受试者的行为和眼球运动指标。对扫视类任务的准确率、潜伏期和扫视幅度,以及时钟匹配类任务的准确率、反应时间、扫视样本图像感兴趣区域(AOI)次数、扫视阵列图像感兴趣区域(AOIs)次数和降效分数作为感兴趣眼动指标进行相关性分析;对帕金森病组的临床特征(疾病持续时间、抗帕金森病药物剂量和Hoehn-Yahr分级)与存在疾病效应的眼动指标进行相关性分析。结果扫视类任务中,AMC组与YC组的各项指标比较差异均无统计学意义(P>0.05);与帕金森病组的各项指标比较,AMC组(P=0.003)和YC组(P<0.001)在反向扫视任务中的扫视幅度均增高,差异有统计学意义。时钟匹配类任务中,与YC组比较,AMC组(时钟匹配任务:P=0.005;倒转时钟匹配任务:P=0.008)和帕金森病组(时钟匹配任务:P=0.002;倒转时钟匹配任务:P<0.001)的反应时间均明显延长,差异有统计学意义。与帕金森病组比较,AMC组及YC组在倒转时钟匹配任务中的访问样本图像AOI的扫视次数(AMC组:P=0.011;YC组:P<0.001)、访问�Objective Record and analyze the disease effects and aging effects of eye movement indicators of visual information processing system in target exploration mission through an infrared eye-movement assessment system,and explore the pathogenesis of the visual exploration disorder in patients with Parkinson's disease(PD).Methods It is a cross-sectional study.A total of 32 patients with PD and normal cognition on dopaminergic drugs were recruited(PD group)from the Dyskinesia clinic of Dalian Friendship Hospital from October 2020 to June 2021;33 age-,gender-and education-matched healthy volunteers with normal cognition were recruited(AMC group)from the medical center of our hospital,and 33 gender-and education-matched healthy young medical intern volunteers were recruited(YC group)from medical interns in our hospital during the same period.Behavioral and eye-movement indicators of all subjects were recorded with an infrared eye movement assessment system by testing to figure-matching tasks representing the visual information processing(clock-matching task and inverted clock-matching task)and saccade tasks representing the oculomotor function.The accuracy,saccade latency,and saccade size of saccade tasks,as well as the accuracy,the reaction time,the number of saccades visiting the sample area of interest(AOI),the number of saccades visiting array AOIs,and the de-efficiency score of clock matching tasks were analyzed.The PD group's clinical characteristics(disease duration,doses of anti-Parkinsonian medication,and Hoehn-Yahr grading)and eye movement indicators with disease effect were analyzed.Results In saccade tasks,there was no significant difference in all indicators between AMC group and YC group(P>0.05).Compared with the indicators of PD group,the saccade amplitude of anti-saccade task increased in AMC group(P=0.003)and the YC group(P<0.001)with statistically significant difference.In clock-matching tasks,compared with the YC group,the reaction time of the AMC group(clock-matching task:P=0.005;reverse clock-matchi

关 键 词：帕金森病 视觉探索 眼动 扫视 认知 衰老 

分 类 号：R742.5[医药卫生—神经病学与精神病学]