AB092.Database for the anatomopathological,functional and surgical characterization of the cornea  

作　　者：Jean Meunier Mona Dagher Julia Talajic Marie-Claude Robert Isabelle Brunette 

机构地区：[1]Département d'informatique et de recherche opérationnelle,Universitéde Montréal,Montréal,QC,Canada [2]Département Neurosciences,CHUM Research Center,Montréal,QC,Canada [3]Département ophtalmologie,Universitéde Montréal,Montréal,QC,Canada [4]Centre Michel-Mathieu,Institut d’excellence en ophtalmologie,Pavillon Maisonneuve,Hôpital Maisonneuve-Rosemont,Montréal,QC,Canada [5]Centre Universitaire d'Ophtalmologie de l'Universitéde Montréal et Centre de Recherche de l'Hôpital Maisonneuve-Rosemont,CIUSSS-E,Montréal,Canada [6]Hôpital Maisonneuve-Rosemont Research Center,CIUSSS-E,Montréal,Canada

出　　处：《Annals of Eye Science》2018年第1期498-498,共1页眼科学年鉴（英文）

摘　　要：Background:The purpose of this infrastructure is to provide to the Network researchers a database and diverse related tools for the anatomical and functional analysis of the normal,pathological and surgical cornea.Methods:This database is composed of normal and pathological individuals,totaling more than 36,000 patients.It includes anatomical and functional imaging data,physiological optics data,psychometric and clinical data(medical history,surgical parameters,acuteness,etc.).Various corneal topography tools were added,giving the database a unique character:tools for analyzing individual maps,average map tools for the study and comparison of populations,3D modeling and visualization tools,statistical tools,etc.There are also screening tools for detecting various corneal conditions(LASIK,PRK,RK,keratoconus)and for secure data exchange between colleagues.Results:Several studies were made in recent years thanks to this common infrastructure.For example,this database has provided important information regarding the evolution of the 3D shape of the normal cornea with age and ametropia and has confirmed the mirror symmetry of corneas for the right and the left eyes(enantiomorphism).The different stages of Fuchs’dystrophy were also characterized to provide essential knowledge for surgery of the posterior layer of the cornea.Our database also allowed studying the anatomy of the wounds and the shape of the cornea before and after a transfixing transplant or an endothelial transplant(DSAEK and DSEK).The data on the characterization of experimentally transplanted corneas with corneal equivalents generated by tissue engineering and the recent addition of clinical data on the replacement of a diseased cornea with a synthetic corneal equivalent(keratoprosthesis)also resulted in several publications.More recently,the database has allowed to develop innovative algorithms to determine the optimal shape of an implant according to the clinical parameters of the recipient.On the other hand,we also demonstrated that the 3D shape o

关 键 词：CORNEA corneal topography ATLAS KERATOPROSTHESIS TRANSPLANT BIOMETRICS 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]