急性胰腺炎胰酶异常活化和分泌的分子机制  

Research advances in abnormal activation and secretion of pancreatic enzymes in acute pancreatitis

作　　者：崔恬玉 刘瑞霞 阴赪宏[1] CUI Tianyu;LIU Ruixia;YIN Chenghong(Department of Internal Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China;Department of Central Laboratory,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院内科,北京100026 [2]首都医科大学附属北京妇产医院中心试验室,北京100026

出　　处：《临床肝胆病杂志》2022年第5期1198-1202,共5页Journal of Clinical Hepatology

基　　金：北京市教育委员会科技计划一般项目(KM201910025007);国家自然科学基金(81571933)。

摘　　要：胰腺腺泡细胞内胰酶异常活化和分泌是急性胰腺炎(AP)的重要发病机制之一,可直接损伤胰腺组织加速疾病进程,诱发重症急性胰腺炎。目前临床抑制胰酶异常活化和分泌的药物效果欠佳,探寻新的治疗靶点十分重要。本文归纳了AP胰酶异常活化和分泌的病理事件(胞浆钙离子超载、溶酶体与酶原颗粒的共定位、细胞器损伤、胰酶顶端侧分泌受阻和基底侧分泌增加等),搜集了相关事件的分子机制,讨论了胰酶异常活化和分泌在AP早期的作用过程,为未来靶向药物的研发提供思路。Abnormal activation and secretion of pancreatic enzymes in pancreatic acinar cells is one of the important pathogeneses of acute pancreatitis(AP)and can directly damage the pancreatic tissue to accelerate disease progression and induce severe AP.At present,the drugs inhibiting the abnormal activation and secretion of pancreatic enzymes tend to have an unsatisfactory effect in clinical practice,and therefore,it is of great importance to search for new therapeutic targets.This article summarizes the pathological events of abnormal activation and secretion of pancreatic enzymes(cytoplasmic calcium overload,colocalization of lysosomes and zymogen granules,organelle injury,obstructed apical secretion of trypsin,and increased basal secretion of trypsin),collects the molecular mechanisms of related events,and discusses the role of abnormal activation and secretion of pancreatic enzymes in the early stage of AP,so as to provide ideas for the development of targeted drugs in the future.

关 键 词：胰腺炎 胰酶 分泌小泡 

分 类 号：R73[医药卫生—肿瘤]